The Growth Restriction Intervention Trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction - 19/08/11
, Neil Marlow, DMFMedSci b, Lisa Upstone, DClinPsy b, Harriet Gross, PhD b, Janet Hornbuckle, MD, MB, MRCOG e, Andy Vail, MSc c, Dieter Wolke, PhD d, Jim G. Thornton, MD, FRCOG b
Reprints: Dawn-Marie Walker, PhD, Community Health Sciences, 14th Floor, the Tower, University of Nottingham, Nottingham NG7 2RD, United KingdomRésumé |
Objective |
The Growth Restriction Intervention Trial found little difference in overall mortality or 2-year outcomes associated with immediate or deferred delivery following signs of impaired fetal health in the presence of growth restriction when the obstetrician was unsure whether to deliver. Because early childhood assessments have limited predictive value, we reevaluated them.
Study Design |
Children were tested with standardized school-based evaluations of cognition, language, motor performance, and behavior. Analysis and interpretation were Bayesian.
Results |
Of 376 babies, 302 (80%) had known outcome: either dead or evaluated at age 6-13 years. Numbers of children dead, or with severe disability: 21 (14%) immediate and 25 (17%) deferred groups. Among survivors, the mean (SD) cognition scores were 95 (15) and 96 (14); motor scores were 8.9 (7.0) and 8.7 (6.7); and parent-assessed behavior scores were 10.5 (7.1) and 10.5 (6.9), respectively, for the 2 groups.
Conclusion |
Clinically significant differences between immediate and deferred delivery were not found.
Le texte complet de cet article est disponible en PDF.Key words : cognitive function, neuropsychology, pediatric, premature
Plan
| Sponsored by the United Kingdom Medical Research Council, which had no involvement with the study design, collection analysis, or interpretation of the data, the writing of the report, or the decision to submit the manuscript. |
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| Cite this article as: Walker D-M, Marlow N, Upstone L, et al. The Growth Restriction Intervention Trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. Am J Obstet Gynecol 2011;204:34.e1-9. |
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| Acknowledgements and the countries, centers, and principal local investigators of the Growth Restriction Intervention Trial study group who participated in the 6- to 9-year follow-up are listed at the end of this article. |
Vol 204 - N° 1
P. 34.e1-34.e9 - janvier 2011 Retour au numéro
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