Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials - 19/08/11
, Anthony J. Senagore, M.B.A., M.D. b, Eugene R. Viscusi, M.D. c, Bruce G. Wolff, M.D. d, John Fort, M.D. e, Wei Du, Ph.D. e, Lee Techner, D.P.M. e, Bruce Wallin, M.D. e
Corresponding author. Tel.: +1-216-844-7981; fax: +1-216-844-8201Abstract |
Background |
This analysis examines gastrointestinal recovery in patients who underwent bowel resection (BR) in 3 recent trials.
Methods |
Patients who underwent BR in the placebo groups of 3 randomized, double-blind, phase III, parallel-group, multicenter alvimopan efficacy trials were analyzed.
Results |
Most patients tolerated solid food and had a bowel movement by postoperative day 4. The majority of patients were discharged from the hospital by day 6, but 24.4% required a prolonged hospital stay or readmission. The incidence of nausea was highest on the day of surgery and decreased thereafter, whereas vomiting was uncommon on the day of surgery but increased slightly on postoperative days 1 to 6. The incidence of postoperative nasogastric tube insertion was highest (12%) on day 2.
Conclusions |
This analysis provides valuable clinical insight into gastrointestinal recovery after BR in a large homogenous patient population receiving multimodal care.
Le texte complet de cet article est disponible en PDF.Keywords : Alvimopan, Bowel resection, Hospital discharge, Nausea, Postoperative ileus, Vomiting
Plan
Vol 191 - N° 3
P. 315-319 - mars 2006 Retour au numéro
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