The Persistence of Transplanted Amniotic Membrane in Corneal Stroma - 19/08/11
, Takahiro Nakamura, MD, PhD a, Andrew J. Quantock, PhD b, Shigeru Kinoshita, MD, PhD a
Inquiries to Che J. Connon, PhD, School of Optometry and Vision Sciences, Cardiff University, CF10 3NB, United Kingdom; fax +44(0)29 20874859Résumé |
Purpose |
To characterize the long-term incorporation of transplanted amniotic membrane into corneal stroma.
Design |
Experimental study.
Methods |
Rabbit amniotic membrane, stained with a fluorescent dye (DTAF), was implanted unilaterally into the corneal stroma of four adult rabbits. Corneas were examined clinically and by transmission electron microscopy and fluorescent microscopy at 1, 3, 7, and 10 months after surgery.
Results |
Visibility of the transplanted amniotic membrane, in situ, on slit-lamp examination decreased over time. However, fluorescent and electron microscopy clearly demonstrated that the amniotic membrane remained structurally unchanged and intact within the corneal stroma up to 10 months after implantation.
Conclusions |
Amniotic membrane allografts persist intact within an intracorneal space for many months postoperatively and are not quickly broken down or dissolved by the host tissue.
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Vol 141 - N° 1
P. 190-192 - janvier 2006 Retour au numéro
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