High-dose vs low-dose oxytocin for labor augmentation: a systematic review - 19/08/11
Reprints: William D. Fraser, MD, MSc, Department of Obstetrics and Gynecology, Université de Montréal, 3175 Chemin de la Côte Sainte-Catherine, Montreal (Quebec), Canada H3T 1C5Résumé |
The objective of this systematic review was to estimate the efficacy and safety of high-dose vs low-dose oxytocin for labor augmentation on the risk of cesarean section and on indicators of maternal and neonatal morbidity. We searched PubMed, MEDLINE, EMBASE, and the Cochrane Library for randomized clinical trials published until January 2010. Ten randomized clinical trials, including 5423 women, met the inclusion criteria. High-dose oxytocin was associated with a moderate decrease in the risk of cesarean section (relative risk [RR], 0.85; 95% confidence interval [CI], 0.75–0.97), a small increase in spontaneous vaginal delivery (RR, 1.07; 95% CI, 1.02–1.12), and a decrease in labor duration (mean difference: –1.54 hours, 95% CI, –2.44 to –0.64). While hyperstimulation was increased with high-dose oxytocin (RR, 1.91; 95% CI, 1.49–2.45), there was no evidence of an increase in maternal or neonatal morbidity. We conclude that high-dose oxytocin for labor augmentation is associated with a decrease in cesarean section and shortened labor.
Le texte complet de cet article est disponible en PDF.Key words : active management, augmentation, oxytocin dose
Plan
| Dr Fraser was supported by a Canada Research Chair from the Canadian Institutes of Health Research (CIHR), Drs Wei and Xu by a scholarship from the CIHR Strategic Training Initiative in Research in Reproductive Health Sciences, and Dr Luo by a junior scholar award from the Fonds de Recherche en Sante du Quebec and a CIHR New Investigator Award. |
Vol 203 - N° 4
P. 296-304 - octobre 2010 Retour au numéro
Article précédent
- Interdisciplinary perspectives on race, ethnicity, and class in recommendations for intrauterine contraception
- Lisa H. Harris
- Twins: prevalence, problems, and preterm births
- Suneet P. Chauhan, James A. Scardo, Edward Hayes, Alfred Z. Abuhamad, Vincenzo Berghella
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?