Immunologic Markers, Uveitis, and Keratoconjunctivitis Sicca Associated with Human T-Cell Lymphotropic Virus Type 1 - 19/08/11
, Olindo A. Martins-Filho, PhD b, JoÃo Gabriel R. Ribas, MD b, c, Bernadette C. Catalan-Soares, MD, PhD a, Fernando A. Proietti, MD, ScD d, Sueli Namen-Lopes, MD a, Gustavo E.A. Brito-Melo, MD, PhD e, Anna Baŕbara F. Carneiro-Proietti, MD, PhD aGIPH (Interdisciplinary HTLV-I/II Research Group)
Inquiries to Sônia Regina A. A. Pinheiro, MD, PhD, Av. Brasil, 1438/1303, Belo Horizonte, Minas Gerais 30.140-003, BrazilRésumé |
Purpose |
To verify the occurrence of keratoconjunctivitis sicca (KCS) and human T-cell lymphotropic virus type 1 (HTLV-1) associated uveitis (HAU) and to evaluate the immunologic status related to HTLV-1.
Design |
Cross-sectional study.
Methods |
Ophthalmic examination (both eyes) and immunophenotyping of peripheral blood lymphocytes were performed in 207 infected asymptomatic blood donors (AS), 55 controls (NI), and 55 patients with HTLV-1 associated myelopathy (HAM/TSP). Examiner was masked to patient’s serologic status.
Results |
KCS was more frequent in HAM/TSP (30/55, 54.5%) than in NI and AS (07/55, 12.7% and 42/207, 20.3%, respectively). Presence of lacrimal hyposecretion in KCS individuals was higher in the HAM/TSP group (P < .001) as compared with NI and AS. HAU was found in 1/55 (1.82%) of HAM/TSP patients and 4/207 (1.93%) of HTLV-1 seropositive donors. Higher levels of activated CD4+ and CD8+ T cells were observed in HAM/TSP. Patients with HAU displayed higher percentage of both CD4+ HLA-DR+ and CD8+HLA-DR+ when compared with NI and AS without HAU.
Conclusions |
Patients with HAM/TSP manifested more ophthalmologic symptoms than asymptomatic HTLV-1–infected individuals, with significantly higher KCS and immunologic alterations. Levels of activated CD8+ T cells could be used as a prognosis marker of inflammatory disease manifestation to follow-up AS individuals.
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| Supported by Capes, Esplanada dos Ministérios, Brasil, Fapemig, Belo Horizonte, Brasil, and CNPq, Asa Norte, Brasil. |
Vol 142 - N° 5
P. 811 - novembre 2006 Retour au numéro
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