Histological and biomechanical evaluation of implanted graft materials in a rabbit vaginal and abdominal model - 20/08/11
, Andrew Walter, MD b, Mark E. Zobitz, MS c, Kevin O. Leslie, MD d, Paul Magtibay, MD a, Jeffrey Cornella, MD a
Reprint requests: Wesley S. Hilger, MD, Division of Gynecologic Surgery, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259.Abstract |
Objective |
The objective of the study was to describe the histologic and biomechanical changes of implanted dermal collagen graft materials.
Study design |
Twenty rabbits were randomized into 2 groups (6 and 12 weeks, respectively). Each rabbit had 4 graft segments (human dermis, porcine dermis, porcine collagen-coated polypropylene mesh, and autologous fascia) randomly implanted into the abdomen and the vagina. Biomechanical testing and histologic analysis was performed after recovery of graft segments.
Results |
Dermal graft segments showed a marked decrease in ultimate strength (84% to 86%) and elastic modulus (73% to 82%) that was significantly different from the decrease seen in autologous fascia or coated synthetic mesh (P < .0008 and P < .0001, respectively). The decrease in ultimate strength was associated with vaginal implantation (P = .057). Dermal graft materials had moderate inflammation and minimal collagen infiltration.
Conclusion |
The mechanical properties of dermal graft materials decline after implantation. Vaginal implantation may cause a different tissue response to graft material than abdominal implantation. Dermal graft material caused moderate inflammation and minimal collagen ingrowth remote from implantation.
Le texte complet de cet article est disponible en PDF.Key words : Dermal graft material, Vaginal reconstruction, Rabbit model
Plan
| Supported by Mayo Foundation for Education and Research. Presented at the 32nd Annual Meeting of the Society of Gynecologic Surgeons, April 3-5, 2006, Tucson, Arizona. |
Vol 195 - N° 6
P. 1826-1831 - décembre 2006 Retour au numéro
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