Erectile Dysfunction: Pathophysiologic Mechanisms Pointing to Underlying Cardiovascular Disease - 21/08/11
Address for reprints: Peter Ganz, MD, Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115.Résumé |
Evidence exists that erectile dysfunction (ED) is analogous to endothelial dysfunction, a known precursor to atherosclerosis in terms of molecular mechanisms and underlying risk factors. These findings are discussed, along with the biologic underpinnings for the clinical observation that ED is an “early warning system” for atherosclerosis. Molecular mechanisms of ED as potential targets of novel therapies are considered, as well as the role of phosphodiesterase 5 inhibitors—currently the most effective treatment of ED—as promising therapies of cardiovascular diseases characterized by endothelial dysfunction.
Le texte complet de cet article est disponible en PDF.Plan
Vol 96 - N° 12S2
P. 8-12 - décembre 2005 Retour au numéro
Article précédent
- Heart Disease Risk Factors Predict Erectile Dysfunction 25 Years Later (The Rancho Bernardo Study)
- Elizabeth Barrett-Connor
- Endothelial and Erectile Dysfunction, Diabetes Mellitus, and the Metabolic Syndrome: Common Pathways and Treatments?
- Vivian Fonseca, Ali Jawa
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?