Urinary 8-Hydroxy-2′-Deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events - 21/08/11
Doi : 10.1016/j.amjcard.2004.09.062
Yasuhiro Nagayoshi, MD a, Hiroaki Kawano, MD a, ⁎ 
, Jun Hokamaki, MD a, Shinzo Miyamoto, MD a, Sunao Kojima, MD a, Hideki Shimomura, MD b, Kenichi Tsujita, MD b, Tomohiro Sakamoto, MD a, Michihiro Yoshimura, MD a, Hisao Ogawa, MD a
, Jun Hokamaki, MD a, Shinzo Miyamoto, MD a, Sunao Kojima, MD a, Hideki Shimomura, MD b, Kenichi Tsujita, MD b, Tomohiro Sakamoto, MD a, Michihiro Yoshimura, MD a, Hisao Ogawa, MD a a Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
b Department of Cardiology, Fukuoka Tokushukai Medical Center, Fukuoka, Japan
*Dr. Kawano's address is: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City 860-8556, Japan
Résumé |
We assessed serial changes in oxidative stress in patients with acute myocardial infarction by measuring urinary 8-hydroxy-2′-deoxyguanosine excretion. The urinary 8-hydroxy-2′-deoxyguanosine creatinine levels peaked at 4 hours after reperfusion therapy and the levels were higher in the cardiac event group than in the noncardiac event group before and after reperfusion.
Le texte complet de cet article est disponible en PDF.| This study was supported in part by a Research Grant for Cardiovascular Disease 14A-1, 14C-4 from the Ministry of Health and Welfare, a grant-in-aid for scientific research B(2)15290248, C14770318, C12203001 and C13670729 from the Ministry of Education, Science, Tokyo, Japan, a Culture and a Smoking Research Foundation Grant for Biomedical Research, Tokyo, Japan, and a Cardiovascular Research Foundation, Japan Heart Foundation/Pfizer Grant for Research on Hypertension, Hyperlipidemia, and Vascular Metabolism, Tokyo, Japan. |
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Vol 95 - N° 4
P. 514-517 - février 2005 Retour au numéro
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