Effects of Carvedilol Upon Intra- and Interventricular Synchrony in Patients With Chronic Heart Failure - 21/08/11
, Paul Mc-Nab, MD a, Juan Carlos Quintana, MD a, Alex Bittner, MD a, Douglas Greig, MD a, Ismael Vergara, MD a, José Luis Vukasovic, MD b, Ramón Corbalan, MD a, Miguel Copaja, BSc c, d, Guillermo Díaz-Araya, PhD c, d, Mario Chiong, BSc c, d, Rodrigo Troncoso, BSc c, d, Hernán Alcaino, BSc c, d, Sergio Lavandero, PhD b, c, d
Corresponding author: Tel.: 56-2-3543334; fax: 56-2-6392037.Résumé |
Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes.
Le texte complet de cet article est disponible en PDF.| Dr. Castro was supported in part by FONDECYT (Santiago, Chile) grant 1010992 and Dr. Lavandero by FONDAP (Santiago, Chile) grant 1501006. |
Vol 96 - N° 2
P. 267-269 - juillet 2005 Retour au numéro
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