Chemotherapy for Retinoblastoma - 21/08/11
, Brenda L. Gallie, MD b, c, Francis L. Munier, MD d, Maja Beck Popovic, MD eRésumé |
Retinoblastoma is the most common eye cancer in children. Pilot studies of chemotherapy for intraocular retinoblastoma have been reported by several groups, using different combinations, dosages, schedules, and durations of carboplatin, etoposide, or teniposide, with or without vincristine, and with or without cyclosporine to counteract multidrug resistance. All studies of chemotherapy for intraocular retinoblastoma have included consolidation by focal therapy, with or without radiation. Chemotherapy alone reduces tumor size but does not cure retinoblastoma. Focal therapy, consisting of photocoagulation, thermotherapy, cryotherapy, or brachytherapy, is necessary to consolidate chemotherapy response.
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| The authors have no financial interest in the subject or materials discussed in this article. This work was supported by grants from the Ontario Cancer Research Network (HSLC and BLG) and the National Cancer Institute of Canada (HSLC and BLG). |
Vol 18 - N° 1
P. 55-63 - mars 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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