Sweat Testing Infants Detected by Cystic Fibrosis Newborn Screening - 21/08/11
, Anne Marie Comeau, PhD, Henry L. Dorkin, MD, Mark Dovey, MD, Robert Gerstle, MD, Thomas Martin, MD, Brian P. O’Sullivan, MD
Reprint requests: Richard Parad, MD, MPH, Massachusetts Cystic Fibrosis Newborn Screening Program, New England Newborn Screening Program of University of Massachusetts Medical School, 305 South St, Jamaica Plain, MA 02130.Abstract |
Objective |
Describe and define limitations of early pilocarpine iontophoresis (sweat testing) for cystic fibrosis (CF) newborn screening (NBS).
Study design |
Population-based results from follow-up of CF NBS–positive newborns.
Results |
Insufficient quantity of sweat is more likely if the sweat test is done too early, but testing is generally successful after 2 weeks of age. Sweat chloride levels drop over the first weeks of life. CF carriers have higher sweat chloride concentrations than non-carriers.
Conclusions |
Sweat testing can be performed effectively after 2 weeks of age for CF NBS–positive newborns. Earlier testing has a higher risk of insufficient sweat for completing testing.
Le texte complet de cet article est disponible en PDF.Mots-clés : CF, DBS, IRT, MA, NBS, QNS, [Cl−], [Na+]
Plan
| Supported by a grant from the CFF. |
Vol 147 - N° 3S
P. S69-S72 - septembre 2005 Retour au numéro
Article précédent
- Quality of Life of Children with Cystic Fibrosis
- Rebecca L. Koscik, Jeffrey A. Douglas, Kathleen Zaremba, Michael J. Rock, Mark L. Splaingard, Anita Laxova, Philip M. Farrell
- Newborn screening for cystic fibrosis in Wisconsin: nine-year experience with routine trypsinogen/DNA testing
- Michael J. Rock, Gary Hoffman, Ronald H. Laessig, Greg J. Kopish, Thomas J. Litsheim, Philip M. Farrell
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