A Randomized, Double-Blind, Placebo-Controlled Trial of Metoclopramide for the Treatment of Tourette’s Disorder - 21/08/11
, Beth Craven-Thuss, M.A., Judy Smith, B. Duncan Mckinlay, Ph.D., F. Xavier Castellanos, M.D.ABSTRACT |
Objective |
The pattern of dopamine antagonism by metoclopramide suggests benefits in the treatment of tic disorders. The purpose of this study was to examine the efficacy and safety of metoclopramide in the treatment of children and adolescents with tic disorders.
Method |
Twenty-seven medication-free patients (age 11.9 ± 2.7 years) with Tourette’s disorder or a chronic tic disorder participated in an 8-week double-blind, randomized, placebo-controlled trial of metoclopramide. Metoclopramide was started at 5 mg daily and titrated as needed to a maximum dose of 40 mg daily. Tics were rated every 2 weeks, and adverse effects, including weight, cardiac, and laboratory measures, were monitored.
Results |
After 8 weeks of treatment, subjects receiving metoclopramide showed a 39% reduction in their total tic score on the Yale Global Tic Severity Scale, while subjects receiving placebo showed only a 13% reduction in tic severity (p = .001). Metoclopramide was well tolerated with no significant laboratory or cardiac changes noted other than an increase in serum prolactin.
Conclusions |
The results of this small controlled study suggest that metoclopramide is an effective and well-tolerated treatment for children and adolescents with tic disorders. Further trials are needed to confirm its efficacy and safety in pediatric patients and adults.
Le texte complet de cet article est disponible en PDF.Key Words : Tourette’s, disorder, treatment, dopamine antagonist, metoclopramide
Plan
| Presented at the Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Miami Beach, 2003. This work was supported by a grant from the Tourette Syndrome Association, Inc. Disclosure: Dr. Castellanos receives research support from McNeil Consumer & Specialty Pharmaceuticals. The other authors have no financial relationships to disclose. |
Vol 44 - N° 7
P. 640-646 - juillet 2005 Retour au numéro
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