Trends in state/population-based Down syndrome screening and invasive prenatal testing with the introduction of first-trimester combined Down syndrome screening, South Australia, 1995-2005 - 22/08/11
, Robert Cocciolone, BAppSc 2, Eric A. Haan, FRACP 2, Chris Wilkinson, FRANZCOG 1, Heather Scott 2, Leonie Sage, RN 3, Renata Bird 2, Rhonda Hutchinson, MSc 2, Annabelle Chan, FAFPHM 3
Reprints: Peter R. Muller, MD, Perinatal Medicine, Women’s and Children’s Hospital, 72 King William Road, North Adelaide, South Australia, Australia 5006Résumé |
Objective |
The purpose of this study was to review trends in the us of maternal serum Down syndrome screening and invasive prenatal testing before and after the introduction of a state-based first-trimester combined Down syndrome screening program.
Study Design |
A retrospective population-based study was performed on first- and second-trimester Down syndrome screening, invasive prenatal testing, and prenatal detection of Down syndrome from 1995 to 2005 in South Australia with data from state-based registers. Chi-square tests were used to evaluate trends.
Results |
There was a significant decrease in the use of second-trimester Down syndrome maternal serum screening (from 75% in 1995 to 25% in 2005; P < .001) and a corresponding significant increase in first-trimester combined screening (from 0.8% in 2000 to 49% in 2005; P < .001). The proportion of all confinements that involved invasive prenatal testing fell (from 9.3% in 1995 to 7.6% in 2005; P < .001). There was a significant decrease in the number of invasive prenatal tests that were needed to detect 1 Down syndrome fetus (from 86 tests in 1995 to 40 tests in 2005; P < .001), with no significant change in the proportion of Down syndrome cases that were detected prenatally.
Conclusion |
The introduction and increased use of first-trimester combined Down syndrome screening has been associated with more efficient use of invasive prenatal testing in South Australia and has maintained a high level of overall prenatal detection.
Le texte complet de cet article est disponible en PDF.Key words : Down syndrome, screening, first-trimester combined screening, prenatal diagnosis, aneuploidy
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| Cite this article as: Muller PR, Cocciolone R, Haan EA, et al. Trends in state/population-based Down syndrome screening and invasive prenatal testing with the introduction of first-trimester combined Down syndrome screening, South Australia, 1995-2005. Am J Obstet Gynecol 2007;196:315.e1-315.e7. |
Vol 196 - N° 4
P. 315.e1-315.e7 - avril 2007 Retour au numéro
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