Generic and additional names: Capreomycin sulfate

CAS name: 3,6-diamino-N-[[(8E)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide sulfuric acid

CAS registry #: 11003-38-6

Molecular formula: C₂₅H₄₆N₁₄O₁₂S

Molecular weight: 766.786

Intellectual property rights: Generic. Polypeptide antibiotic isolated from Streptomyces capreolus.

Brand names: Capastat, Capastat sulfate, Capreomycin, Capreomycin sulphate, Ogostal, Capreomycin IA, Capreomycin IB

Solubility: Soluble in water. Practically insoluble in most organic solvents [Merck Index].

Polarity: pKa in 66% aqueous DMF: 6.2, 8.2, 10.1, 13.3 [Merck Index]. Log P −9.609 [DrugBank].

Stability: Stable in aqueous solution at pH 4–8; unstable in strongly acidic or strongly basic solutions [Merck Index].

Formulation and optimal human dosage: 1 g vial, 1 g daily, i.v. or intramuscularly (i.m.)