Stenting for malignant colonic obstruction: a comparison of efficacy and complications in colonic versus extracolonic malignancy - 23/08/11
, Riad R. Azar, MD, Steven A. Edmundowicz, MD, Qin Zhang, MS, Tarek Ammar, MD, Bhaskar Banerjee, MD, Dayna S. Early, MD, Sreenivasa S. Jonnalagadda, MD
Reprint requests: Rajesh N. Keswani, MD, 676 North St Clair, 14th Floor, Northwestern University, Chicago, IL 60611.St. Louis, Missouri, USA
Abstract |
Background |
Self-expandable metal stent placement for palliation of malignant colonic obstruction for colorectal cancer (CRC) is safe and efficacious. In contrast, outcomes of stent placement for extracolonic malignancy (ECM) are unclear.
Objective |
To compare the success and complication rates of colorectal stenting in patients with CRC versus those with ECM.
Design |
Retrospective chart review.
Setting |
Tertiary-care academic medical center.
Patients and Interventions |
Between September 2000 and December 2007, all patients with malignant colon obstruction in whom endoscopy was performed with the intention of placing a colonic metal stent.
Main Outcome Measurements |
Technical and clinical success rates, surgical interventions, and procedure-related complications.
Results |
Colonic stenting was performed for CRC in 34 patients and for ECM in 15 patients. Patients with CRC were more likely to have clinical success after all endoscopic therapy (94.1%) than those with ECM (20.0%) (P < .0001). Surgical diversion to relieve persistent obstructive symptoms was required in significantly more patients with ECM. Five patients with ECM (33.3%) had at least one complication, including 2 deaths, compared with 3 patients with CRC (8.8%) (P = .046). Only underlying ECM was predictive of failed colon stent placement by multivariate analysis (hazard ratio 21.0, P = .0013). A history of radiation therapy was the sole predictor of complications (hazard ratio 7.8, P = .048).
Limitations |
Single institution, retrospective analysis, relatively small sample size.
Conclusions |
Colon stenting for large-bowel obstruction from ECM is infrequently successful and is associated with a significantly higher risk of complications in comparison with patients with CRC.
Le texte complet de cet article est disponible en PDF.Abbreviations : CRC, ECM
Plan
| DISCLOSURE: The following authors disclosed financial relationships relevant to this publication: S. Edmundowicz: Receives research support, acts as a consultant, and is on the medical advisory board for Boston Scientific Corp. R. Azar, S. Jonnalagadda: Received honoraria from Boston Scientific Corp. Boston Scientific Corp has provided research and program support to the gastroenterology division of Washington University. All other authors disclosed no financial relationships relevant to this publication. |
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| If you want to chat with an author of this article, you may contact him at rajman@gmail.com. |
Vol 69 - N° 3P2
P. 675-680 - mars 2009 Retour au numéro
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