Prenatal glucocorticoid exposure and postnatal adaptation in premature newborn baboons ventilated for six days - 25/08/11
, A.Kimberly Altamirano, MD a, M.Gore Ervin, PhD b, Steven R. Seidner, MD c, Alan H. Jobe, MD, PhD d
Reprint requests: Lynne M. Smith, MD, Martin Research Center, Box 446, Harbor-UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502.Abstract |
Objective |
Renal and cardiovascular function is improved during the first 24 hours of life in preterm ventilated baboons exposed to prenatal betamethasone (BETA). We hypothesized BETA-induced effects would be sustained through day 6 of life.
Study design |
Pregnant baboons received saline or BETA (6 mg) 48 and 24 hours before preterm delivery at 125 days' gestation. The newborn baboons were ventilated for 6 days, and assessed for renal, cardiovascular, and endocrine function.
Results |
Mean arterial blood pressure (MAP) and glomerular filtration rate (GFR) values 24 hours after delivery were higher in the BETA group. Kidney Na, K-ATPase activity was higher in the BETA group by day 6. All other measures were similar in both groups by day 6.
Conclusion |
Prenatal BETA exposure in the premature baboon: (1) increases MAP and GFR on day 1 without measurable effects by day 6 and (2) increases kidney Na, K-ATPase activity.
Le texte complet de cet article est disponible en PDF.Keywords : Betamethasone, Renal, Cardiovascular, Endocrine, Baboon
Plan
 | Supported in part by grants HL-052635 and HL-53636 (The Southwest Foundation for Biomedical Research BPD Resource Center) from the National Institutes of Health, an Established Investigatorship Award to M.G.E. from the American Heart Association, and grant 3 M01 RR00425-2754 from the National Institutes of Health, General Clinical Research Center Branch to L.M.S. |
Vol 191 - N° 5
P. 1688-1694 - novembre 2004 Retour au numéro
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