Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy - 25/08/11

Doi : 10.1016/j.ajo.2004.06.016

Ralph D. Levinson, MD ^a,⁎ , Raja Rajalingam, PhD ^b, Min S. Park, DVM ^b, Elaine F. Reed, PhD ^b, David W. Gjertson, PhD ^b, Peter J. Kappel, MD ^a, Robert F. See, MD ^c, Narsing A. Rao, MD ^c, Gary N. Holland, MD ^a
^a Ocular InflammatoryDisease Center and Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, California, USA (R.D.L., P.J.K., G.N.H.)
^b Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Immunogenetics Center, Los Angeles, California, USA (R.R., M.S.P., E.F.R., D.W.G.)
^c David Geffen School of Medicine at UCLA; the Doheny Eye Institute, University of Southern California Keck School of Medicine (R.F.S., N.A.R.), Los Angeles, CaliforniaUSA

^*Inquiries to Ralph D. Levinson MD, Jules Stein Eye Institute, 100 Stein Plaza, UCLA, Los Angeles, CA 90095-7002; fax: (310) 794-7906

Résumé

Purpose

To determine whether birdshot retinochoroidopathy is associated with subtypes of the human leukocyte antigen (HLA)-A29 other than HLA-A*2902.

Design

Experimental study.

Methods

High-resolution DNA typing of HLA-A29 subtypes was performed on blood from 20 subjects with birdshot retinochoroidopathy using polymerase chain reaction–based typing methods. Results were compared with published controls.

Results

Four of 20 subjects (20%) had the HLA-A*2901 allele; two were homozygous for HLA-A*29, and both had the HLA-A*2901 and HLA-A*2902 alleles. Among 18 subjects with only one HLA-A*29 allele, the HLA-A*2902 allele was found in 16 (89%) and the HLA-A*2901 allele was found in two (11%). No subject was found to have HLA-A*2903, HLA-A*2904, HLA-A*2905, or HLA-A*2906.

Conclusions

Both HLA-A*2901 and HLA-A*2902 are associated with birdshot retinochoroidopathy. Our data do not support the previous suggestion that the HLA-A29.1 serotype may be protective against development of birdshot retinochoroidopathy. Additional studies will be required to determine whether the other, less common subtypes are associated with the disease. HLA-A29 subtype testing is not required for the clinical evaluation of HLA-A29–positive patients with birdshot retinochoroidopathy.

Le texte complet de cet article est disponible en PDF.

Plan

Methods

Results

Discussion

Supported in part by Research to Prevent Blindness, Inc, New York, New York (G.N.H.); the MacDonald Family Foundation, Los Angeles California (R.D.L.); the Skirball Foundation, Los Angeles, California (G.N.H.); and the David May II Endowed Professorship (G.N.H.). Dr Holland is a recipient of a Research to Prevent Blindness Physician-Scientist Award.

Export

Vol 138 - N° 4

P. 631-634 - octobre 2004 Retour au numéro

Article précédent

Analysis of irises with a latanoprost-induced change in iris color
Esther Arranz-Marquez, Miguel A. Teus, M.Antonia Saornil, M.Carmen Mendez, Raquel Gil

| Article suivant

Posterior capsule opacification and YAG capsulotomy
Stephen S. Lane

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy - 25/08/11

Résumé

Purpose

Design

Methods

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL