Relationship between airway phagocyte CD11b and CD14 expression and ozone-induced airway inflammation in human volunteers - 25/08/11
Abstract |
Rationale |
Inhaled ozone, like endotoxin, induces airway neutrophilia in humans. We examined whether ozone-induced inflammation modifies airway macrophage mCD14 expression, and whether constitutive CD11b expression on circulating phagocytes predicts the magnitude of the neutrophil response following ozone exposure.
Methods |
Twenty two (N=22) volunteers underwent controlled exposure to ozone (400ppb, 2hr) and to filtered air. Induced sputum and peripheral blood were collected before and after exposure.
Results |
Induced sputum revealed marked neutrophilia, and flow cytometric analysis showed that mCD14 expression on airway macrophages and monocytes was significantly increased following ozone exposure. A significant and positive correlation (R=0.89, p=0.002) was found between baseline CD11b expression on blood phagocytes and ozone-induced airway neutrophilia.
Conclusions |
Inhaled ozone enhances the expression of mCD14 on airway phagocytes in human volunteers and circulating CD11b predicts the magnitude of the airway neutrophil response following ozone exposure. CD11b may be a useful biomarker for predicting susceptibility to neutrophilic inflammation in the airway due to pollutants.
Le texte complet de cet article est disponible en PDF. | Funding: US EPA: CR-829522 |
Vol 113 - N° 2S
P. S258 - février 2004 Retour au numéro
Article précédent
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