CRTH2 polymorphism : Genetic risk factor for near-fatal asthma in the Chinese childhood population - 25/08/11
Abstract |
Rationale |
Interaction of CRTH2 and its natural ligand, PGD2, play a critical role in the recruitment and activation of inflammatory cells in the asthmatic airways. We conducted a case-control study to test the genetic association of two CRTH2 polymorphisms (1544G/C and 1651A/G) and asthma in a cohort of Chinese children
Methods |
Genomic DNA and clinical data were obtained from three groups of Chinese children: 44 near-fatal asthmatics, 94 mild-to-moderate asthmatics, and 59 nonasthmatic-nonatopic controls.
Results |
Our results revealed that the frequencies of CRTH2
1544C (SNP#1) and 1651G (SNP#2) alleles were both significantly higher in asthmatic children compared with the nonasthmatic-nonatopic controls (OR: 2.908, P=0.043 and OR: 3.690, P<0.001, respectively). Haplotype analysis provided significant evidence of association for the 1544G-1651G haplotype (p<0.0000001) with asthma. Moreover, the frequency of 1651G allele in near-fatal asthmatics (90.9%) was significantly higher than mild-to-moderate asthmatics (73.6%, OR: 3.582, P=0.001) and normal controls (50.9%, OR: 9.655, P<0.001). The 1651G allele was also associated with a higher degree of bronchial hyperresponsiveness.
Conclusions |
Our results suggest that CRTH2 polymorphisms influence the susceptibility to and modulate the severity of asthma.
Le texte complet de cet article est disponible en PDF. | Funding: Self-funded |
Vol 113 - N° 2S
P. S340 - février 2004 Retour au numéro
Article précédent
- Manchester asthma and allergy study : Polymorphisms in ADAM33 predict lung function at age 5 years
- A. Simpson, F. Jury, J. Cakebread, L. Lowe, S. Holgate, A. Woodcock, W. Ollier, A. Custovic, J. Holloway, S. John
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