Enterally dosed recombinant human erythropoietin does not stimulate erythropoiesis in neonates - 29/08/11
Abstract |
Objectives |
Human fetuses and neonates ingest erythropoietin (Epo) when they swallow amniotic fluid, colostrum, and human milk. This study was designed to determine whether enterally dosed recombinant Epo (rEpo) stimulates erythropoiesis in preterm neonates.
Methods |
Preterm infants (<1500 g birth weight) were randomly assigned to receive feedings supplemented with either rEpo (1000 U/kg per day) or placebo for 14 days (n=36). Reticulocyte counts, serum Epo concentrations, hematocrit, and zinc protoporphyrin to heme ratios were measured at baseline and after 7 and 14 days of study drug administration. Transfusion guidelines were followed. Transfusion requirements, medications, feeding tolerance, and clinical diagnoses were documented.
Results |
Enteral rEpo was well tolerated. There were no differences in erythropoietic indexes based on treatment group. Serum Epo concentrations were not different in the treatment versus placebo group, nor were transfusion requirements.
Conclusions |
Enterally dosed rEpo (1000 U/kg/day) does not significantly influence erythropoiesis or iron utilization when given for a 2-week period, nor does it elevate the serum Epo concentration in preterm or term infants. Oral administration of rEpo is not an effective substitute for parenteral administration.
Le texte complet de cet article est disponible en PDF.Abbreviations : Epo, GI, HCT
Plan
A portion of this work was conducted through the Clinical Research Center Facility at the University of Washington and supported by the National Institutes of Health, grants M01-RR-00037 and RR00082. |
Vol 143 - N° 3
P. 321-326 - septembre 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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