Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration - 03/09/11
, Hiroshi Obayashi, PhD b, Gouji Hasegawa, MD, PhD b, Naoto Nakamura, MD, PhD b, Toshikazu Yoshikawa, MD, PhD b, Yutaka Imamura, MD a, Kan Koizumi, MD c, Shigeru Kinoshita, MD, PhD cAbstract |
PURPOSE: Paraoxonase (E.C.3.1.1.2) is a polymorphic protein shown to prevent low-density lipoprotein oxidation. Our purpose is to evaluate the hypothesis that paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level play a role in the occurrence of exudative age-related macular degeneration.
METHODS: We analyzed paraoxonase genotypes (A/B, Gln-Arg192 and L/M, Leu-Met54) and plasma oxidized low-density lipoprotein levels in 72 unrelated Japanese patients with exudative age-related macular degeneration and compared the results with those of 140 age-matched and sex-matched control subjects.
RESULTS: The distribution of paraoxonase 192 and paraoxonase 54 polymorphisms was significantly different between the patients with age-related macular degeneration and control subjects (chi-square = 6.226, P = .0445, and chi-square = 6.863, P = .0323, respectively). The high frequency of the BB genotype at position 192 was observed in the exudative age-related macular degeneration group compared with control subjects (52.8% vs 35.0%, respectively; P = .0127). The high frequency of the LL genotype at position 54 was observed in the patients more than the controls (91.7% vs 77.1%, respectively; P = .0090). The mean (± SE) oxidized low-density lipoprotein levels in the patients was significantly higher than in the controls (19.1 ± 1.0 vs 16.2 ± 0.6 U/ml, P < .01).
CONCLUSION: These results indicate that the paraoxonase gene polymorphisms may represent a possible genetic risk factor for age-related macular degeneration and that increased plasma oxidized low-density lipoprotein may be involved in the pathogenesis of age-related macular degeneration.
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| ☆ | This study was supported in part by a grant in-aid for scientific research 08672031 from the Ministry of Education, Culture, and Science of Japan, a research grant from Kyoto Foundation for the Promotion of Medical Science, and the intramural research fund of Kyoto Prefectual University of Medicine. |
Vol 132 - N° 2
P. 191-195 - août 2001 Retour au numéro
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