Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm - 04/09/11
Abstract |
Dendritic cells are now recognized as the gatekeepers of the immune response, possessing a unique potential for acquisition of antigens at extremely low exposure levels and for efficient presentation of these in an immunogenic form to the naive T-cell system. Dendritic cell populations throughout the body exhibit a wide range of features in common that are associated with their primary functions, and these are considered in the initial section of this review. In addition, it is becoming evident that the properties and functions of these cells are refined by microenvironmental factors unique to their tissues of residence, a prime example being mucosal microenvironments such as those in respiratory tract tissues, and the latter represents the focus of the second section of this review. (J Allergy Clin Immunol 2000;105:421-9.)
Le texte complet de cet article est disponible en PDF.Keywords : Dendritic cells, immunoregulation, TH1/2, lung, T-cell activation, inflammation
Abbreviations : APC:, DC:, M-CSF:, MIIC:, NO:, RLN:, TH1/2:
Plan
 | Reprint requests: P. G. Holt, DSc, FRCPath, Division of Cell Biology, TVW Telethon Institute for Child Health Research, PO Box 855, West Perth WA 6872, Australia. |
Vol 105 - N° 3
P. 421-429 - mars 2000 Retour au numéro
Article précédent
- The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium
- Donald V. Belsito
- IL-13 genetics: Pale rider or horse of a different color?
- Lanny J. Rosenwasser
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?