Minimal access surgery for cholelithiasis induces an attenuated acute phase response - 08/09/11
Abstract |
Background: Some benefits of laparoscopic (LC) and minilaparotomy (MC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.
Methods: Patients were randomized to LC (n = 11) or MC (n = 11). C-reactive protein (CRP), ⍺-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-⍺) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.
Results: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P <0.05). Alterations in CRP, AAT, and albumin were similar. Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.
Conclusions: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique.
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 | This work was supported by an Aberdeen Royal Hospitals NHS Trust endowment grant. |
Vol 178 - N° 3
P. 232-234 - septembre 1999 Retour au numéro
Article précédent
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