Both soluble guanylate cyclase and particulate guanylate cyclase regulate myometrial contractility - 09/09/11
Abstract |
OBJECTIVE: Our purpose was to compare the effects of agents stimulating particulate and soluble guanylate cyclase with spontaneous rat uterine contractions at midgestation and term.
STUDY DESIGN: Uterine rings from midgestation (day 13) and term nonlaboring (day 22) rats were positioned in organ chambers for isometric force recording. Rings were treated with increasing concentrations of atrial natriuretic peptide, permeable analogs of cyclic guanosine monophosphate, and diethylamine/nitric oxide.
RESULTS: Atrial natriuretic peptide was more effective in inhibition of uterine contractions than diethylamine/nitric oxide. The 50% inhibitory concentrations were –7.4 ± 0.12 and –7.38 ± 0.11 for atrial natriuretic peptide and –5.68 ± 0.09 and –4.23 ± 0.12 for diethylamine/nitric oxide at midgestation and term, respectively. Pretreatment of uterine rings with atrial natriuretic peptide significantly attenuated inhibition of spontaneous contractions by diethylamine/nitric oxide at midgestation.
CONCLUSIONS: Uterine spontaneous contractions are influenced by both soluble and particulate guanylate cyclase; the former, but not latter, is gestational age dependent. (Am J Obstet Gynecol 1998;179:111-6.)
Le texte complet de cet article est disponible en PDF.Keywords : Myometrium, soluble guanylate cyclase, particulate guanylate cyclase, atrial natriuretic factor, nitric oxide
Plan
 | From Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch,a and Research Laboratories, Schering AG.b |
| Reprint requests: Robert E. Garfield, PhD, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Rte 1062, Galveston, TX 77555-1062. |
 | 0002-9378/98 $5.00 + 0 6/1/88327 |
Vol 179 - N° 1
P. 111-116 - juillet 1998 Retour au numéro
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