Non-A, non-B, non-C hepatitis: Its significance in pediatric patients and the role of GB virus-C - 11/09/11
Abstract |
Objectives: To delineate the importance of non-A, non-B, non-C (non-ABC) hepatitis, and the role of GB virus C (GBV-C) in children.
Methods: From 1980 to 1995, acute-onset viral hepatitis was diagnosed in 166 inpatients and categorized into type A, B, C, and non-ABC hepatitis according to the serologic markers or the results of polymerase chain reaction assay for HBV DNA or HCV ribonucleic acid (RNA) in the National Taiwan University Hospital. Non-ABC hepatitis was diagnosed in 57 patients (34%). GBV-C RNA was investigated by reverse transcription and nested polymerase chain reaction in 32 of the 57 patients with non-ABC hepatitis. The clinical and laboratory features of patients with acute non-ABC hepatitis were compared with the features of those with acute hepatitis A and B.
Results: The degree of abnormality in aminotransferase activities was milder in patients with non-ABC hepatitis than in those with hepatitis B; chronicity was noted in 12%. Fulminant hepatitis occurred in 16%, and the mortality rate was 56%. Young age carried a significantly higher risk of having a fulminant course (1.9 ± 0.2 years of age vs 6.4 ± 5.1 years of age in acute course; p < 0.05). Compared with fulminant hepatitis B, fulminant non-ABC hepatitis had a trend of a longer interval from onset to death (119.2 ± 144.8 vs 15.2 ± 8.4 days; p = 0.079). GBV-C RNA was detected in only two of the patients tested, both of whom had received transfusions; one had persistent viremia and fluctuating aminotransferase values.
Conclusions: Non-ABC hepatitis plays an important role in the etiology of pediatric viral hepatitis; however, the role of GBV-C is minor. A search for other unknown viral agent(s) responsible for non-ABCG hepatitis is needed. (J Pediatr 1997;131:536-40)
Le texte complet de cet article est disponible en PDF.Abbreviations : ALT, AST, GBV-C, HBcAg, HBsAG, HBV, HCV, HEV, NANB, Non-ABC, NTUH, PCR, RNA
Plan
 | Supported by a grant from the National Science Council, Republic of China (NSC86-2315-B002-004-MH). |
| Reprint requests: Mei-Hwei Chang, MD, Department of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shan S. Rd., Taipei, Taiwan. |
 | aPresent address: Department of Pediatrics, Taipei Municipal Chung-Hsiao Hospital, Taipei, Taiwan |
| bPresent address: Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan |
| ♢ | 9/21/82425 |
Vol 131 - N° 4
P. 536-540 - octobre 1997 Retour au numéro
Article précédent
- Descriptive epidemiology of adverse events after immunization: Reports to the Vaccine Adverse Event Reporting System (VAERS), 1991-1994
- M.Miles Braun, Susan S. Ellenberg, From the Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland
- High iron status in very low birth weight infants is associated with an increased risk of retinopathy of prematurity
- T.E. Inder, R.S. Clemett, N.C. Austin, P. Graham, B.A. Darlow, From the Departments of Paediatrics, Ophthalmology, and Public Health and General Practice, Christchurch School of Medicine, and the Department of Paediatrics and Child Health, Dunedin School of Medicine, University of Otago, New Zealand.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?