SPECT abnormalities in generalized dystonia - 12/09/11
, S. Lane Rutledge, MD †, James M. Mountz, MD,PhD ‡, Jaykrishna T. Darji, BS †Abstract |
A patient with severe, generalized dystonia and 6 age range-matched controls were studied with the regional cerebral blood flow tracer technetium-99m hexamethylpropyleneamine oxime by single-photon emission computed tomography to test the hypothesis that cerebellar function is abnormal in dystonia. Analysis was performed by drawing regions of interest around the caudate head nuclei, hemithalami, deep cerebellar nuclei, and cerebellar hemicortices. The counts in each region of interest were normalized to whole brain cerebral blood flow in an identical manner for each subject. The dystonic patient had a difference in regional cerebral blood flow between the right and left deep cerebellar nuclei, increased regional cerebral blood flow in subcortical motor structures, and an abnormal relationship between right cerebellar cortical and right deep cerebellar nuclear regional cerebral blood flow. The findings in this patient provide evidence that the cerebellum may play a role in the pathophysiology of motor signs in some patients with dystonia.
Le texte complet de cet article est disponible en PDF. | MSL was supported by grants from the National Institutes of Health (K08 NS01592-01) and the Research Foundation of the American Association of Neurological Surgeons. We thank Dr. Joan F. Lorden for critically reviewing this manuscript. |
Vol 13 - N° 1
P. 5-10 - juillet 1995 Retour au numéro
Article précédent
- Editorial Board
- Familial infantile olivopontocerebellar atrophy
- Erawati V. Bawle, William J. Kupsky, Constance J. D'Amato, Cristie J. Becker, Sam Hicks
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?