A comparison between two screening methods for detection of microproteinuria - 12/09/11
Reprint requests: Kenneth Higby, MD, Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.Abstract |
OBJECTIVE: We compared two screening tests for microproteinuria with 24-hour quantitative measurements to determine which method is better at predicting clinically significant proteinuria.
STUDY DESIGN: We obtained 690 24-hour urine collections from both low- and high-risk patients seen for prenatal care. Qualitative screening for microproteinuria on the basis of the protein-error-of-indicators principle (Ames Multistix 10SG and Micro-bumintest, Miles Diagnostic Division, Elkhart, Ind.) was done by the same investigator (C.S.). Quantitative assay was done by use of pyrogallol red-molybdate for total protein and by radioimmunoassay for albumin.
RESULTS: The Micro-bumintest had a sensitivity of 87% compared with 36% for the Multistix 10SG. It also had a higher specificity and higher positive and negative predictive values. The Micro-bumintest was a better screening test in patients with significant protein excretion (>300 mg/24 hours).
CONCLUSION: The Micro-bumintest has a much higher sensitivity and a lower false-negative rate than does the Multistix 10SG. Our data support the Micro-bumintest as a better screening test for clinically significant proteinuria.
Le texte complet de cet article est disponible en PDF.Keywords : Proteinuria, microalbuminuria, Multistix 10SG, Micro-bumintest
 | Presented in part at the Fifteenth Annual Meeting of the Society of Perinatal Obstetricians, Atlanta, Georgia, January 23–28, 1995. |
| The opinions expressed herein are those of the authors and not necessarily those of the Department of the Army or the Department of Defense. |
Vol 173 - N° 4
P. 1111-1114 - octobre 1995 Retour au numéro
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