First-trimester screening in triplets - 01/10/11
, Terrence W. Hallahan, PhD a, Kuanglin He, PhD a, John E. Sherwin, PhD a, Mark I. Evans, MD b
Reprints: David A. Krantz, MA, NTD Laboratories, Inc, 80 Ruland Rd., Suite 1, Melville, NY 11747Résumé |
Objective |
The purpose of this study was to determine the performance of Down syndrome screening in triplet pregnancy.
Study Design |
Nuchal translucency (NT; n = 794), nasal bone (n = 219), and biochemistry (n = 198) were evaluated in triplet pregnancy. Screening performance was evaluated with the use of delta and Gaussian models.
Results |
The median multiples of the median values for free beta human chorionic gonadotropin and pregnancy-associated plasma protein A were 2.86 and 3.48, respectively. A significant correlation in delta NT within pregnancy was observed (0.46-0.68). The modeled false-positive rates were 11.7%, 7.4%, and 8.9% with the delta model and 11.9%, 6.6%, and 12.0% with the Gaussian model for NT, NT + nasal bone, and NT + biochemistry. Based on simulation, the detection rate at 12 weeks' gestation was 78%, 93%, and 80% for NT, NT + nasal bone, and NT + biochemistry at a 10% false-positive rate using either the delta or Gaussian models.
Conclusion |
In triplet pregnancy, the addition of nasal bone lowers the false-positive rate of nuchal translucency screening. More data are required on the effectiveness of biochemistry.
Le texte complet de cet article est disponible en PDF.Key words : Down syndrome, free beta hCG, pregnancy-associated plasma protein A, triplet pregnancy, ultrasound screening
Plan
| T.W.H., K.H., and J.E.S. and D.A.K. are employees of NTD Laboratories, a subsidiary of PerkinElmer Inc. M.I.E. is a consultant for PerkinElmer Inc. NTD Laboratories and PerkinElmer Inc have substantial corporate interests in prenatal screening for Down syndrome. |
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| Cite this article as: Krantz DA, Hallahan TW, He K, et al. First-trimester screening in triplets. Am J Obstet Gynecol 2011;205:364.e1-5. |
Vol 205 - N° 4
P. 364.e1-364.e5 - octobre 2011 Retour au numéro
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