Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card - 11/10/11
Doi : 10.1016/j.jpeds.2011.06.032
Volker Strenger, MD a, ⁎ 
, Klaus Pfurtscheller, MD a, Gerald Wendelin, MD a, Stephan W. Aberle, MD b, Elisabeth P. Nacheva, MD, PhD c, Bettina Zöhrer, MD a, Werner Zenz, MD a, Bert Nagel, MD a, Gerfried Zobel, MD a, Therese Popow-Kraupp, MD b
, Klaus Pfurtscheller, MD a, Gerald Wendelin, MD a, Stephan W. Aberle, MD b, Elisabeth P. Nacheva, MD, PhD c, Bettina Zöhrer, MD a, Werner Zenz, MD a, Bert Nagel, MD a, Gerfried Zobel, MD a, Therese Popow-Kraupp, MD b a Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria
b Department of Virology, Medical University of Vienna, Vienna, Austria
c Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
Reprint requests: Volker Strenger, MD, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.Abstract |
To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6.
Le texte complet de cet article est disponible en PDF.Mots-clés : CSF, FISH, HHV-6, iHHV-6, MRI, PCR
Plan
| The authors declare no conflicts of interest. |
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Vol 159 - N° 5
P. 859-861 - novembre 2011 Retour au numéro
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