Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension - 23/12/11
Corresponding author. University of Giessen Lung Center, University Hospital Giessen, Klinikstrasse 33, 35392 Giessen, Germany. Tel.: +49 641 985 56751; fax: +49 641 985 42599.Summary |
Background |
Patients with pulmonary arterial hypertension often present with a mild obstructive lung pattern, however, the functional consequences are not known.
Methods |
We analysed flow volume loops during exercise in 61 patients with precapillary pulmonary hypertension (PH) (age 55 ± 14 years) in comparison with 21 patients with COPD (60 ± 12 years), 39 patients with pulmonary fibrosis (58 ± 11 years) and 38 healthy controls (HC) (39 ± 15 years). Inspiratory capacity (IC) was measured at rest, and during maximum exercise (max).
Results |
HC exhibited a stable IC of 3.0 ± 0.9 l at rest, and at max. A reduction in IC of 2.6 ± 0.8 l at rest to 2.0 ± 0.7 l at max was observed in patients with COPD. Patients with PH exhibited a significant reduction in IC from 2.3 ± 0.6 l at rest to 2.1 ± 0.6 l at max, while patients with pulmonary fibrosis exhibited a stable IC of 1.8 ± 0.6 at rest and 1.7 ± 0.6 l at max. In patients with PH, a weak negative correlation was drawn between the change in IC (%) and peak VO2 (r = −0.29, p = 0.01), as well as with PVR (r = −0.27, p = 0.02).
Conclusion |
Patients with PH demonstrate a characteristic change in IC during exercise, which might contribute to impaired exercise tolerance.
Le texte complet de cet article est disponible en PDF.Keywords : Pulmonary hypertension, Exercise, Dynamic hyperinflation
Plan
Vol 106 - N° 2
P. 308-313 - février 2012 Retour au numéro
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