A case of methamphetamine use disorder treated with the antibiotic drug minocycline - 02/02/12
, Minoru Shimagami, M.D. b, Goro Fukami, M.D., Ph.D. a, Yoshimoto Sekine, M.D., Ph.D. c, Masaomi Iyo, M.D., Ph.D. a, Kenji Hashimoto, Ph.D. dAbstract |
Methamphetamine (METH) use is one of the major public health concerns worldwide. Long-term use of METH induces not only dependence but also psychosis which is associated with METH-induced brain damage, including neuroinflammation produced by activated microglia. We report the case of a female patient whose psychotic symptoms in METH use disorder were successfully improved by anti-inflammatory drug minocycline therapy. Although the precise mechanism(s) underlying the efficacy of minocycline in METH use disorder are currently unclear, minocycline appears to be a good candidate for future investigation clinical trials for medication development in METH using populations.
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| ☆ | No authors had any disclosures to make. |
Vol 32 - N° 5
P. 559.e1-559.e3 - septembre 2010 Retour au numéro
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