Elevated Concentrations of Inflammation-Related Proteins in Postnatal Blood Predict Severe Developmental Delay at 2 Years of Age in Extremely Preterm Infants - 12/02/12
, Elizabeth N. Allred 2, 3, 4, Karl C.K. Kuban, MD, Sm Epidem 5, Olaf Dammann, MD 6, Nigel Paneth, MD, MPH 7, Raina Fichorova, MD, PhD 2, 8, Deborah Hirtz, MD 9, Alan Leviton, MD 2, 4Extremely Low Gestational Age Newborn (ELGAN) Study Investigators
Reprint requests: T. Michael O’Shea, MD, MPH, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157.Abstract |
Objective |
To evaluate the hypothesis that elevated levels of inflammation-related proteins in early postnatal blood predict impaired mental and motor development in extremely preterm infants.
Study design |
We measured concentrations of 25 inflammation-related proteins in blood collected on postnatal days 1, 7, and 14 from 939 infants born before 28 weeks gestation. An elevated level was defined as a concentration in the highest quartile for gestational age and day of blood collection. We identified impaired development at age 24 months using the Bayley Scales of Infant Development, Second Edition. The primary outcomes were scores on the Mental Scale or the Motor Scale of <55 (more than 3 SDs below the mean).
Results |
For 17 of the 25 inflammation-related proteins, 1 or more statistically significant associations (P<.01) was found between an elevated blood level of the protein and a developmental impairment. Elevations on multiple days were more often associated with developmental impairment than were elevations present for only 1 day. The highest number of predictive elevations was found in day-14 blood.
Conclusion |
In extremely preterm infants, elevated levels of inflammation-related proteins in blood collected on postnatal days 7 and 14, especially when sustained, are associated with impaired mental and motor development at age 2 years.
Le texte complet de cet article est disponible en PDF.Mots-clés : BSID-II, ELGAN, GMFCS
Plan
| Supported by the National Institute of Neurological Disorders and Stroke (Grant NS 40069). This study was completed as a cooperative agreement with the National Institute of Neurological Disorders and Stroke. The study sponsor participated in the study design, but not in the data collection or data analysis. The authors declare no conflicts of interest. |
Vol 160 - N° 3
P. 395 - mars 2012 Retour au numéro
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