T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity - 17/03/12
Corresponding author. Tel.: +34 955013291; fax: +34 955013292.Summary |
Objectives |
Analyze the short-term immunological effect directly attributable to MRV without interference of other drugs.
Methods |
MRV group included experienced HIV-infected patients undergoing an 8-day MRV monotherapy. A comparison population included naïve HIV-infected patients starting combined antiretroviral therapy (cART group). Absolute CD4+ and CD8+ T-cells and T-lymphocyte subsets were determined at day 0 and 8.
Results |
Fifty-nine patients who underwent MRV monotherapy and 28 naïve patients were analyzed. Forty-one patients in the MRV group experienced a significant viral load decrease (MRV positive subgroup). Virological response and CD4+ T-cell change were comparable in the MRV positive and cART groups. CD8+ T-cell increase in the MRV positive subgroup showed a trend toward superiority when compared with the cART group. T-lymphocyte subset changes showed a similar profile in the MRV positive and cART groups with a differential effect in the TemRA cells related to MRV. No immunological effect (absolute lymphocyte counts or subsets) was observed in patients without virological response to MRV.
Conclusions |
MRV produced CD4+ and CD8+ T-cell gains related to antiviral activity and comparable or even superior in terms of CD8+ T-cells to naïve patients starting cART. No immunological effect occurred in subjects without virological response to MRV.
Le texte complet de cet article est disponible en PDF.Keywords : HIV, Maraviroc, CCR5 antagonist, CD4-positive T-lymphocytes, Viral tropism
Plan
Vol 64 - N° 4
P. 417-423 - avril 2012 Retour au numéro
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