Insulin Resistance and Adiposity in Relation to Serum β-Carotene Levels - 23/06/12
Abstract |
Objective |
To determine the effects of placebo vs an encapsulated supplement of fruit and vegetable juice concentrate (FVJC) on serum β-carotene levels, insulin resistance, adiposity, and subclinical inflammation in boys.
Study design |
Thirty age-matched prepubertal boys (9 lean and 21 overweight (OW); age range, 6-10 years) were studied. All participants received nutrition counseling and were randomized to receive FVJC or placebo capsules for 6 months. Total cholesterol, triglycerides, lipid corrected β-carotene, serum retinol, glucose, insulin, retinol binding protein-4, leptin, adiponectin, leptin-to-adiponectin ratio, high-sensitivity C-reactive protein, and interleukin-6 were measured before and after the 6-month intervention. Homeostasis model assessment-insulin resistance (HOMA-IR), acute insulin response to intravenous glucose, along with abdominal fat mass (dual-energy x-ray absorptiometry) were also determined.
Results |
Baseline β-carotene concentrations correlated inversely with HOMA-IR, leptin-to-adiponectin ratio, and abdominal fat mass (P≤.01). FVJC intake increased β-carotene concentrations (P≤.001) but did not influence retinol or retinol binding protein-4. Retinol insufficiency <1.047 μM was present in 18% of the entire cohort at baseline and in 37% at 6 months. HOMA-IR decreased after supplementation in the OW cohort, when adjusted for percent weight change (P=.014). The percent change in abdominal fat mass increased in the placebo group and decreased in the FVJC group (P=.029).
Conclusions |
A 6-month supplementation with FVJC in the presence of nutritional counseling was associated with an increase in serum β-carotene concentrations and a reduction in adiposity in conjunction with an improvement in insulin resistance in OW boys.
Le texte complet de cet article est disponible en PDF.Mots-clés : AIR, BMI, FFQ, FVJC, HDL, GDI, HOMA-IR, HS-CRP, IR, IL-6, L/A, LCβC, OW, QUICKI, RBP4, SR
Plan
Funded by the Nemours Research Program. The placebo and active study capsules were a gift from NSA, LLC (Collierville, TN), manufacturer of Juice Plus+. J.C.’s spouse, who is a pediatrician, is a distributor for NSA, LLC, and promotes the product in her practice. The other authors declare no conflicts of interest. |
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Registered with ClinicalTrials.gov: NCT00842543. |
Vol 161 - N° 1
P. 58 - juillet 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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