Comparison of standard forward-viewing mode versus ultrawide-viewing mode of a novel colonoscopy platform: a prospective, multicenter study in the detection of simulated polyps in an in vitro colon model (with video) - 13/02/13
Reprint requests: Ian M. Gralnek, MD, MSHS, FASGE, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, GI Outcomes Unit, Department of Gastroenterology, Rambam Health Care Campus, Haifa, IsraelRésumé |
Background |
Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed.
Objective |
To compare forward-viewing with ultrawide-viewing colonoscopy in the detection of simulated colon polyps in an in vitro colon model.
Design |
Prospective, multicenter.
Setting |
Six endoscopy units (3 in the United States and 3 in Israel).
Patients |
In vitro colon model with simulated colon polyps (n = 21 metallic beads).
Interventions |
Detection of simulated colon polyps on colonoscope withdrawal.
Main Outcome Measurements |
Incremental detection of simulated colon polyps and endoscopist evaluation of the usability, visibility, and maneuverability of ultrawide-viewing colonoscopy.
Results |
On forward-viewing colonoscopy, the number of simulated polyps (mean ± standard deviation) detected per endoscopist was 11.1 ± 2.3 polyps, a 52.9% detection rate. Simulated polyp detection rates per colon segment were 3.0 ± 0.93 (60.0%) right colon, 2.4 ± 0.87 (48.0%) transverse colon, and 5.7 ± 1.5 (51.8%) left colon. On ultrawide-viewing colonoscopy, the simulated polyp detection rate per endoscopist significantly increased to 18.0 ± 1.98 polyps, an overall 85.7% polyp detection rate (P < .001). Simulated polyp detection rates were also significantly higher by using the ultrawide-viewing mode in each colon segment, 4.5 ± 0.65 polyps (90.0%) right colon, 4.0 ± 0.87 (80.0%) polyps transverse colon, and 9.6 ± 1.28 polyps (87.3%) left colon (all comparisons, P < .001). Importantly, the ultrawide-viewing mode detected significantly more “hidden” simulated polyps (81.9% vs 31.9%, P < .0001).
Limitations |
Nonrandomized design, use of a colon model, and “simulated” colon polyps.
Conclusions |
Ultrawide-view colonoscopy significantly improved simulated polyp detection in a colon model. Clinical studies in human subjects should be pursued to further evaluate this new endoscopic technology.
Le texte complet de cet article est disponible en PDF.Abbreviations : MCU, TER
Plan
| DISCLOSURE: Drs Gralnek, Halpern, Siersema, Carr-Locke, Segol, and Suissa are consultants for Peer Medical Ltd. Dr Segev is the Medical Director of Peer Medical Ltd. This study was sponsored by Peer Medical Ltd, Caesaria, Israel. |
Vol 77 - N° 3
P. 472-479 - mars 2013 Retour au numéro
Article précédent
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