Neoadjuvant therapy for rectal cancer decreases the number of lymph nodes harvested in operative specimens - 16/02/13
Corresponding author. Tel.: +1-814-453-2777; fax: +1-814-453-2779.Abstract |
Background |
We evaluated the effect of neoadjuvant therapy (NAT) on lymph node harvest in rectal cancer patients undergoing anatomic resection with curative intent.
Methods |
A prospectively maintained database was retrospectively queried for rectal cancer cases from 1990 to 2010. Demographic data, NAT, and lymph node yield were analyzed. Nonanatomic resections were excluded.
Results |
Five hundred two cases were identified; the mean age was 68 years (range 34–89), and 56% were men. One hundred fifty-one (30%) patients received NAT. Overall, the lymph node yield was diminished in proctectomy specimens after NAT (mean = 9, median = 7) compared with specimens without therapy (mean = 13, median = 10, P = .001). Age was not a significant factor in the lymph node yield (P = .213 and .329). Among patients treated with NAT, younger patients had a significantly lower lymph node yield (P < .0001).
Conclusions |
A decreased lymph node yield in proctectomy specimens from patients treated with NAT is consistent with prior studies. Younger patients had a greater reduction in lymph node harvest after NAT compared with senior patients.
Le texte complet de cet article est disponible en PDF.Keywords : Chemoradiation, Proctectomy, Lymph node, Rectal cancer, Specimen
Plan
| The authors declare no conflicts of interest. |
Vol 205 - N° 3
P. 289-292 - mars 2013 Retour au numéro
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