Intragastric acidity during the first day following administration of low-dose proton pump inhibitors: A randomized crossover study - 06/06/13
, Daisuke Maruoka a, Takeshi Tanaka b, Tomoaki Matsumura a, Takuto Suzuki c, Tomoo Nakagawa a, Tatsuro Katsuno a, Fumio Imazeki a, Osamu Yokosuka a
Corresponding author. Department of Medicine and Clinical Oncology (K1), Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan. Tel.: +81 43 226 2083; fax: +81 43 226 2088.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Objective |
Low-dose proton pump inhibitors (PPIs) are often administrated as maintenance therapy for gastroesophageal reflux disease (GERD) and on-demand PPI therapy is a viable option for long-term management of GERD. The aim of this study is to investigate intragastric acidity during the first day following the administration of low-dose PPIs.
Subjects and methods |
The study employed a crossover design. The subjects were 10 healthy volunteers who were administrated lansoprazole 15mg (orally disintegrating) or rabeprazole 10mg. All subjects underwent pH monitoring with a wireless system during the first day after PPI administration.
Results |
There was no significant difference in the average intragastric pH during the first day of administration of lansoprazole and rabeprazole (3.3±1.1 vs. 3.2±0.7, paired t test), although the pH was significantly higher with both drugs as compared with the baseline (1.8±0.4, P<0.01). The pH 4 holding time ratio during the first day showed no significant difference between lansoprazole and rabeprazole (35.2±22.4% vs. 34.3±15.0%), and was also significantly higher than at baseline (0.35±1.73%, P<0.01). The two PPIs differed with respect to the peak of the pH 4 holding time ratio.
Conclusions |
Lansoprazole 15mg and rabeprazole 10mg showed sufficient inhibition of intragastric acidity during the first day after PPI administration and the effects did not differ between drugs, although there was a difference in their time at which the peak effects were reached.
Le texte complet de cet article est disponible en PDF.Abbreviations : PPI, GERD, H2RA, CYP2C19, EM, IM, PM, OD
Plan
Vol 37 - N° 3
P. 296-301 - juin 2013 Retour au numéro
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