Pediatric Bipolar Disorder Versus Severe Mood Dysregulation: Risk for Manic Episodes on Follow-Up - 21/06/13
, Argelinda Baroni, M.D. a, Caroline Haimm, B.A. a, Melissa Brotman, Ph.D. a, Catherine H. Lowe, M.S.W. a, Frances Myers, R.N., M.S.N. a, Eileen Rustgi, Ph.D. a, Wanda Wheeler, M.S.W. a, Reilly Kayser, B.A. a, Kenneth Towbin, M.D. a, Ellen Leibenluft, M.D. a
Correspondence to Dr. A. Stringaris, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, Denmark Hill, London, SE5 8AF United KingdomRésumé |
Objective |
An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD).
Method |
Patients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes.
Results |
Only one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72).
Conclusions |
These data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes.
Le texte complet de cet article est disponible en PDF.Key Words : bipolar disorder, pediatric, severe mood dysregulation, irritability, ADHD
Plan
| This article was reviewed under and accepted by Ad Hoc Editor David R. Rosenberg, M.D. |
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| This work was supported by the National Institute of Mental Health, Intramural Program. |
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| Disclosure: Drs. Stringaris, Baroni, Brotman, Rustgi, Towbin, and Leibenluft, and Ms. Haimm, Mr. Lowe, Ms. Myers, Ms. Wheeler, and Mr. Kayser report no biomedical financial interests or potential conflicts of interest. |
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| This article is discussed in an editorial by Dr. Robert Althoff on page 302. |
Vol 49 - N° 4
P. 397-405 - avril 2010 Retour au numéro
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