2269 – Evidence for a negative association between schizophrenia and a polymorphism in the insulin receptor substrate-3 (IRS-3) gene - 09/07/13
Résumé |
Introduction |
Since there are clear indications that schizophrenia is a systemic disorder, we sought for a common molecular basis for schizophrenia abnormalities in brain and body. Our hypothesis was that an impaired insulin/ insulin-like growth factor signalling in cells might underlie changes in both brain and body in schizophrenia. In this regard, the intracellular insulin receptor substrates 1-4 proteins might be of interest to study genetically.
Objective/aim |
In this study, we chose to investigate the insulin receptor substrate-3 (IRS-3) gene as a candidate gene in schizophrenia.
Methods |
The IRS-3 gene of 93 patients with the diagnosis of schizophrenia according to DSM-IV criteria and 57 healthy control subjects was screened for DNA sequence variations, followed by case-control analyses of total 10 detected polymorphisms.
Results |
The A/G genotype of the single nucleotide polymorphism (SNP) at position 100166597 in the IRS-3 gene occurred in 5.3% of the control subjects compared with in 0% of the patients (p=0.05).
Conclusion |
Our finding suggests that individuals carrying the A allele of this A/G SNP in the IRS-3 gene have a protection against schizophrenia development.
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Vol 28 - N° S1
P. 1 - 2013 Retour au numéro
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- 2267 – Treatment effect of agomelatine on depressive symptoms and patients' compliance: results of the non-interventional study vital over 6 months
- M. Lemke, B. Barthel
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- F. Frikha, J. Masmoudi, N. Messedi, I. Feki, M. Snoussi, A. Jaoua, Z. Bahloul
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