1121 – Effects on cognitive function in treatment resistant bipolar depression: ECT compared to algorithm based pharmacological treatment - 09/07/13
Résumé |
Introduction |
Electroconvulsive therapy (ECT) is a treatment alternative in bipolar disorder (BD) depression. Cognitive side effects are the major concern limiting its use.
Objectives |
We present data from the Norwegian randomized controlled trial of ECT in treatment resistant depression in bipolar disorder.
Aims |
To compare effects on cognitive function of ECT or algorithm based pharmacological treatment at the end of a six-week acute, BD depression treatment trial.
Methods |
Prospective, randomised controlled multi-centre, six-week acute treatment trial. Pre- and post-treatment assessments with the MATRICS Consensus Cognitive Battery (MCCB); a neuropsychological test battery designed to be sensitive to changes in cognitive function.
Sample |
N = 51 patients ≥ 18 years fulfilling criteria for treatment resistant BD depression (MADRS score ≥25).
Intervention |
ECT group: Three sessions per week for up to six weeks, total up to 18 sessions, and right unilateral electrode placement. Algorithm-based pharmacological treatment group: Based on Goodwin & Jamison, 2007.
Results |
Both groups showed a net gain on MCCB scores without significant differences between the study groups. Mean change in MCCB composite T-score was 4.0 (5.7) in the ECT group and 2.7 (3.6) in the pharmacological group (F =0.78, eta2 =0.021, p =0.383).
Conclusion |
In treatment resistant BD depression ECT and algorithm-based pharmacological treatment have comparable effects on cognitive function assessed with the MATRICS.
Le texte complet de cet article est disponible en PDF.Vol 28 - N° S1
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