Possible Effect of Corticoids on Hemiplegic Attacks in Severe Hemiplegic Migraine - 20/09/13
, Martin Schöning, MD, PhD a, Karin Jurkat-Rott, MD, PhD b, Holger Lerche, MD, PhD cAbstract |
Background |
Sporadic and familial hemiplegic migraines are rare paroxysmal disorders characterized by transient hemiparesis and headache. The distinction is based on whether other family members are affected. In 50% of cases, these migraines are caused by CACNA1 A missense mutations.
Patients |
We describe a boy with a particularly severe phenotype and a de novo R1349Q mutation of the CACNA1 A gene.
Results |
The patient suffered from early-onset profound mental retardation, epileptic seizures, cerebellar ataxia, and progressive cerebellar atrophy. He experienced prolonged attacks of migraine with hemiparesis, seizures, altered consciousness, and fever resulting from minor head traumas. A prolonged hemiplegic attack improved following a 5-day treatment of 100 mg/d methylprednisolone.
Conclusion |
R1349Q mutation of the CACN1 A gene may be associated with a severe phenotype. Corticoids might be beneficial in prolonged hemiplegic attacks.
Le texte complet de cet article est disponible en PDF.Keywords : hemiplegic, migraine, CACNA1A gene, mental retardation, corticoids
Plan
Vol 49 - N° 4
P. 286-288 - octobre 2013 Retour au numéro
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