Atypical Phenotypes in Classical Hodgkin Lymphoma - 17/11/13
Abstract |
Classical Hodgkin lymphoma has a characteristic immunophenotype in most cases, with expression of CD30, CD15, and PAX-5, and absence of CD45 and T-lineage markers. However, in a significant subset of cases, atypical staining patterns may be seen for one or more antigens, particularly negative staining for CD15 or staining for one or more B-lineage markers, such as CD20, CD79a, OCT-2, or BOB.1. The greatest pitfall is in the misinterpretation of other cells, such as immunoblasts or histiocytes, as Hodgkin cells.
Le texte complet de cet article est disponible en PDF.Keywords : Immunohistochemistry, CD30, CD15, PAX-5, CD45, CD20, CD79a, OCT-2, BOB.1
Plan
| Dr Weiss is affiliated with Clarient, a GE Healthcare Company, which is the developer of the Hodgkin lymphoma MultiOmyx laboratory developed test. |
Vol 6 - N° 4
P. 729-742 - décembre 2013 Retour au numéro
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