Folate Pathway Genetic Polymorphisms are Related to Attention Disorders in Childhood Leukemia Survivors - 07/03/14
, Pim Brouwers, PhD b, c, d, Neelam Jain, PhD a, b, Linna Zhang, MD b, c, Lisa Bomgaars, MD b, c, ZoAnn Dreyer, MD b, c, Donald Mahoney, MD b, c, Sarah Bottomley, MN, CPNP c, M. Fatih Okcu, MD, MPH b, c, e
Reprint requests: Kevin R. Krull, PhD, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, 332 N. Lauderdale St, MS 735, Memphis, TN 38105-2794.Résumé |
Objective |
To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy.
Study design |
Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms.
Results |
Eleven of the 48 patients (22.9%) had scores consistent with the inattentive symptoms of ADHD. Patients with genotypes related to lower folate levels (11 out of 39; 39.2%) were more likely to have ADHD. The A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in diagnosis, compared with a 1.3-fold increase for the C677T genotype. Age at diagnosis and sex were not associated with inattentiveness.
Conclusions |
Preliminary data imply a strong relationship between MTHFR polymorphisms and the inattentive symptoms of ADHD in survivors of childhood ALL.
Le texte complet de cet article est disponible en PDF.Abbreviations : ADHD, ALL, CSI, MTHFR, MTX, PCR
Plan
| No author reports any conflict of interest associated with this study. |
Vol 152 - N° 1
P. 101-105 - janvier 2008 Retour au numéro
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