Does Placental Inflammation Relate to Brain Lesions and Volume in Preterm Infants? - 07/03/14
, Leena Haataja, MD, PhD cThe PIPARI Study Group
Reprint requests: Liisa Lehtonen, MD, Department of Pediatrics, Kiinamyllynkatu 4-8, 20520 Turku, Finland.Résumé |
Objectives |
To evaluate the association between histologic inflammation of placenta and brain findings in ultrasound examinations and regional brain volumes in magnetic resonance imaging in very-low-birth-weight (VLBW) or in very preterm infants.
Study design |
VLBW or very preterm infants (n = 121) were categorized into 3 groups according to the most pathologic brain finding on ultrasound examinations until term. The brain magnetic resonance imaging performed at term was analyzed for regional brain volumes. The placentas were analyzed for histologic inflammatory findings.
Results |
Histologic chorioamnionitis on the fetal side correlated to brain lesions in univariate but not in multivariate analyses. Low gestational age was the only significant risk factor for brain lesions in multivariate analysis (P < .0001). Histologic chorioamnionitis was not associated with brain volumes in multivariate analyses. Female sex, low gestational age, and low birth weight z score correlated to smaller volumes in total brain tissue (P = .001, P = .0002, P < .0001, respectively) and cerebellum (P = .047, P = .003, P = .001, respectively). In addition, low gestational age and low-birth-weight z score correlated to a smaller combined volume of basal ganglia and thalami (P = .0002).
Conclusions |
Placental inflammation does not appear to correlate to brain lesions or smaller regional brain volumes in VLBW or in very preterm infants at term age.
Le texte complet de cet article est disponible en PDF.Abbreviations : CRP, IVH, MRI, PROM, VLBW
Plan
| This study was supported by grants from The Lea and Arvo Ylppö Foundation and The South-Western Finnish Foundation of Neonatal Research. |
Vol 152 - N° 5
P. 642 - mai 2008 Retour au numéro
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