Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop - 29/05/14
Doi : 10.1016/j.jaci.2014.01.018
Jean Bousquet, MD a, ⁎ 
, James E. Gern, MD b, Fernando D. Martinez, MD c, Josep M. Anto, MD, PhD d, e, Christine C. Johnson, PhD, MPH f, Patrick G. Holt, ScD g, Robert F. Lemanske, MD b, Peter N. Le Souëf, MD h, Robert S. Tepper, MD, PhD i, Erika R.M. von Mutius, MD, MSc j, S. Hasan Arshad, DM k, Leonard B. Bacharier, MD l, Allan Becker, MD m, Kathleen Belanger, PhD n, †, Anna Bergström, PhD o, David I. Bernstein, MD p, Michael D. Cabana, MD, MPH q, Kecia N. Carroll, MD, MPH r, Mario Castro, MD, MPH s, Philip J. Cooper, PhD t, Matthew W. Gillman, MD, SM u, Diane R. Gold, MD, MPH v, John Henderson, MD w, Joachim Heinrich, PhD, MSc x, Soo-Jong Hong, MD, PhD y, Daniel J. Jackson, MD b, Thomas Keil, MD, MSc z, Anita L. Kozyrskyj, PhD aa, Karin C. Lødrup Carlsen, MD, PhD bb, Rachel L. Miller, MD cc, Isabelle Momas, PhD dd, Wayne J. Morgan, MD, CM ee, Patricia Noel, PhD ff, Dennis R. Ownby, MD gg, Mariona Pinart, PhD d, Patrick H. Ryan, PhD hh, Julie M. Schwaninger, MS ii, Malcolm R. Sears, MB, ChB jj, Angela Simpson, MD, PhD kk, Henriette A. Smit, PhD ll, Debra A. Stern, MS c, Padmaja Subbarao, MD, MSc mm, Rudolf Valenta, MD nn, Xiaobin Wang, MD, MPH, ScD oo, Scott T. Weiss, MD, MS pp, Robert Wood, MD qq, Anne L. Wright, PhD rr, Rosalind J. Wright, MD, MPH ss, Alkis Togias, MD ii, Peter J. Gergen, MD, MPH ii
, James E. Gern, MD b, Fernando D. Martinez, MD c, Josep M. Anto, MD, PhD d, e, Christine C. Johnson, PhD, MPH f, Patrick G. Holt, ScD g, Robert F. Lemanske, MD b, Peter N. Le Souëf, MD h, Robert S. Tepper, MD, PhD i, Erika R.M. von Mutius, MD, MSc j, S. Hasan Arshad, DM k, Leonard B. Bacharier, MD l, Allan Becker, MD m, Kathleen Belanger, PhD n, †, Anna Bergström, PhD o, David I. Bernstein, MD p, Michael D. Cabana, MD, MPH q, Kecia N. Carroll, MD, MPH r, Mario Castro, MD, MPH s, Philip J. Cooper, PhD t, Matthew W. Gillman, MD, SM u, Diane R. Gold, MD, MPH v, John Henderson, MD w, Joachim Heinrich, PhD, MSc x, Soo-Jong Hong, MD, PhD y, Daniel J. Jackson, MD b, Thomas Keil, MD, MSc z, Anita L. Kozyrskyj, PhD aa, Karin C. Lødrup Carlsen, MD, PhD bb, Rachel L. Miller, MD cc, Isabelle Momas, PhD dd, Wayne J. Morgan, MD, CM ee, Patricia Noel, PhD ff, Dennis R. Ownby, MD gg, Mariona Pinart, PhD d, Patrick H. Ryan, PhD hh, Julie M. Schwaninger, MS ii, Malcolm R. Sears, MB, ChB jj, Angela Simpson, MD, PhD kk, Henriette A. Smit, PhD ll, Debra A. Stern, MS c, Padmaja Subbarao, MD, MSc mm, Rudolf Valenta, MD nn, Xiaobin Wang, MD, MPH, ScD oo, Scott T. Weiss, MD, MS pp, Robert Wood, MD qq, Anne L. Wright, PhD rr, Rosalind J. Wright, MD, MPH ss, Alkis Togias, MD ii, Peter J. Gergen, MD, MPH ii a University Hospital, Montpellier and INSERM U1018, Villejuif, France
b University of Wisconsin School of Medicine and Public Health, Madison, Wis
c Arizona Respiratory Center, University of Arizona, Tucson, Ariz
d Centre for Research in Environmental Epidemiology (CREAL) and IMIM (Hospital del Mar Research Institute) and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
e Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain
f Department of Public Health Sciences, Henry Ford Health System, Detroit, Mich
g Telethon Institute for Child Health Research, University of Western Australia, and Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia
h School of Paediatrics and Child Health, Princess Margaret Hospital for Children, University of Western Australia, Perth, Australia
i Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Ind
j Dr. von Hauner Children's Hospital of the University of Munich, Munich, Germany
k Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and the David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom
l Washington University and St Louis Children's Hospital, St Louis, Mo
m Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
n Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, School of Medicine, New Haven, Conn
o Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
p Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio
q Departments of Pediatrics, Epidemiology & Biostatistics, the University of California, San Francisco, Calif
r Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn
s Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo
t Liverpool School of Tropical Medicine, Liverpool, and Escuela de Biologia, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
u Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Mass
v Channing Division of Network Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, and Harvard School of Public Health, Department of Environmental Health, Boston, Mass
w School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
x Helmholtz Zentrum, Muenchen, German Center for Environmental Health, Institute of Epidemiology I, Munich, Germany
y Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
z Institute of Social Medicine, Epidemiology and Health Economics, Charité–Universitaetsmedizin Berlin, Berlin, and Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany
aa Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
bb Oslo University Hospital and University of Oslo, Oslo, Norway
cc Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University, New York, NY
dd Department of Public Health and Biostatistics, Paris Descartes University, Sorbonne, and Paris Municipal Department of Social Action, Childhood, and Health, Paris, France
ee Department of Pediatrics, University of Arizona, Tucson, Ariz
ff Division of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Md
gg Georgia Regents University, Augusta, Ga
hh Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
ii Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
jj Department of Medicine, AstraZeneca Chair in Respiratory Epidemiology, McMaster University, Hamilton, Ontario, Canada
kk Centre for Respiratory and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester and University Hospital of South Manchester, Manchester, United Kingdom
ll Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
mm Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
nn Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
oo Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md
pp Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass
qq Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md
rr Arizona Respiratory Center and the Department of Pediatrics, University of Arizona College of Medicine, Tucson, Ariz
ss Department of Pediatrics and Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY
∗Corresponding author: Jean Bousquet, MD, Centre Hospitalier Montpellier, 34295 Montpellier, Cedex 05, France.
Abstract |
Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. More than 130 birth cohorts focusing on asthma and allergy have been initiated in the last 30 years. A National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Mechanisms of the Development of Allergy (MeDALL; Framework Programme 7 of the European Commission) joint workshop was held in Bethesda, Maryland, on September 11-12, 2012, with 3 objectives: (1) documenting the knowledge that asthma/allergy birth cohorts have provided, (2) identifying the knowledge gaps and inconsistencies, and (3) developing strategies for moving forward, including potential new study designs and the harmonization of existing asthma birth cohort data. The meeting was organized around the presentations of 5 distinct workgroups: (1) clinical phenotypes, (2) risk factors, (3) immune development of asthma and allergy, (4) pulmonary development, and (5) harmonization of existing birth cohorts. This article presents the workgroup reports and provides Web links (AsthmaBirthCohorts.niaid.nih.gov or www.medall-fp7.eu), where the reader will find tables describing the characteristics of the birth cohorts included in this report, the type of data collected at differing ages, and a selected bibliography provided by the participating birth cohorts.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, asthma, birth cohorts, National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Disease (NIAID), Mechanisms of the Development of Allergy (MeDALL)
Abbreviations used : AHR, ECA, FP6, FP7, GA2LEN, GINIplus, LCI, MAS, MeDALL, NHLBI, NIAID
Plan
| Supported by MeDALL (Mechanisms of the Development of Allergy, EU FP7 Grant agreement no. 261357). The workshop was supported in part by funds from the Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, and the Division of Lung Diseases, National Heart, Lung, and Blood Institute. |
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| Disclosure of potential conflict of interest: J. Bousquet is a member of scientific and advisory boards for Actelion, Almirall, Meda, Merck, Merck Sharp Dohme, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach; is on the Board of Directors of Stallergenes; has received payment for lectures from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach; and has received travel support from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva. and Uriach. J. E. Gern has received research support from the National Institutes of Health (NIH), Merck, AstraZeneca, and GlaxoSmithKline and has received personal fees from GlaxoSmithKline, Biota, Centocor, Boehringer, MedImmune, Theraclone, Merck, and Gilead. F. D. Martinez has received grants from the NIH and has received travel support from Abbott and Merck. C. C. Johnson has received research support from the National Institute of Allergy and Infectious Disease (NIAID) and has had consultant arrangements with McNeil. R. F. Lemanske, Jr, has received research support from the NIH/National Heart, Lung, and Blood Institute (NHLBI) and Pharmaxis; has received travel support from the NIH; has received fees for participation in review activities from the NIH; is Secretary/Treasurer of the American Academy of Allergy, Asthma & Immunology (AAAAI); has consultant arrangements with Merck, Sepracor, SA Boney and Associates, GlaxoSmithKline, the American Institute of Research, Genentech, Double Helix Development, and Boehringer Ingelheim; is employed by the University of Wisconsin School of Medicine and Public Health; has received payment for lectures from the Michigan Public Health Institute, Allegheny General Hospital, the American Academy of Pediatrics West Allegheny Health Systems, California Chapter 4, AAP, the Colorado Allergy Society, the Pennsylvania Allergy and Asthma Association, Harvard Pilgrim Health, the California Society of Allergy, the New York City Allergy Society, the World Allergy Organization, the American College of Chest Physicians, APAPARI, and the Western Society of Allergy, Asthma, and Immunology; has received payment for manuscript preparation from the AAAAI; has received royalties from Elsevier and UpToDate. P. N. Le Souëf has received research support from the National Health Medical Research Council of Australia. R. Tepper has received research support from the NIH. E. R. M. von Mutius is Associate Editor of the Journal of Allergy and Clinical Immunology; has consultant arrangements with GlaxoSmithKline, Novartis, Astellas Pharma Europe, and ALK-Abelló; and has received research support from Friesland Campina BV. S. H. Arshad has received research support from the NHLBI and Asthma UK. L. B. Bacharier has consultant arrangements with Aerocrine, GlaxoSmithKline, Genentech/Novartis, Merck, Schering, Cephalon, DBV Technologies, and Teva; has research support from the NHLBI/NIH, AsthmaNet, and VDAART Trial; has received payment for lectures from Aerocrine, AstraZeneca, Genentech/Novartis, GlaxoSmithKline, Merck, Schering-Plough, and Teva. A. Becker has received research support from the Canadian Institute of Health Research/AllergGen NCE, AstraZeneca, Merck Frosst, Novartis, and Pfizer; is a board member for Merck Frosst Canada and Novartis; receives payment for lectures from AstraZeneca, Merck Frosst, and Novartis; and has received payment for the development of educational presentations from Novartis and Pfizer. D. Bernstein has received research support from the National Institute of Environmental Health Sciences and the National Institute of Occupational Safety and Health; has consultant arrangements from Merck, Genentech, and Teva; and has received payment for lectures from Merck. M. D. Cabana has consultant arrangements with Mead Johnson and Abbott Nutrition and has received research support from Nestec and Wyeth Nutrition. M. Castro has received research support from the NIH, Asthmatx/Boston Scientific, Amgen, Ception/Cephalon/Teva, Genentech, MedImmune, Merck, Novartis, GlaxoSmithKline, Sanofi Aventis, Vectura, Next Bio, and KaloBios; has consultant arrangements with Asthmatx/Boston Scientific, Genentech, IPS Holaira, Pulmagen, and Sanofi-Aventis; has received payment for lectures from Merck, GlaxoSmithKline, Genentech, Asthmatx/Boston Scientific, and Boehringer Ingelheim; and has received royalties from Elsevier. P. J. Cooper is employed by the Liverpool School of Tropical Medicine and has received research support from the Wellcome Trust UK. D. R. Gold has received research support from and is employed by the NIH and the US Environmental Protection Agency. J. Henderson has received research support from the Medical Research Council UK and Wellcome Trust and has received travel support from the NIH. D. J. Jackson has received research support from the NHLBI and has consultant arrangements with GlaxoSmithKline and Genentech. T. Keil has received research support from the European Union and is employed by Charite Berlin. K. C. Lødrup Carlsen has received research support from RegionHealth Southeast, ThermoFisher Scientific, Furst Medical Laboratory, Regional Health Board East (Norway), Health and Rehabilitation (Norway), and the Norwegian Research Council and has received travel support from EU-FP7 MeDALL. W. J. Morgan has consultant arrangements with Genentech and the Cystic Fibrosis Foundation and is employed by the University of Arizona; has received research support from the Cystic Fibrosis Foundation, Mount Sinai Hospital/Research Institute, and the NHLBI; has received payment for lectures from the AAAAI and the American Thoracic Society; and has received royalties from Elsevier. D. R. Ownby has received research support from the National Institute of Allergy and Infectious Disease. M. R. Sears has consultant arrangements with AstraZeneca and Novartis and has received payment for lectures from AstraZeneca and Merck. A. Simpson has received research support from the Medical Research Council. R. Valenta has received research support from and has consultant arrangements with Biomay AG and ThermoFisher. S. T. Weiss has consultant arrangements with Novartis. R. Wood has consultant arrangements with the Asthma and Allergy Foundation of America, is employed by Johns Hopkins University, has received research support from the NIH, and has received royalties from UpToDate. A. L. Wright has received research support from the NIH. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2014
Publié par Elsevier Masson SAS.
Vol 133 - N° 6
P. 1535-1546 - juin 2014 Retour au numéro
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