DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma - 16/07/14
Abstract |
Background |
Cutaneous fibrous histiocytoma (FH) is a common mesenchymal neoplasm. Metastasis is rare, disproportionately occurring among the aneurysmal, cellular, atypical, and deep variants.
Objective |
We determined whether DNA copy number changes occurred in atypical FH (AFH), and whether they were similar to those in metastasizing FH (MetFH) and benign cellular FH (CFH).
Methods |
Five primary tumors of MetFH were evaluated by array-based comparative genomic hybridization analysis, with tissue from local recurrences and lung metastases in 2 and 2 patients, respectively. Seven indolent AFH and 5 CFH were identified for comparison.
Results |
Substantial differences between the groups were found both in the frequency of chromosomal aberrations (higher among MetFH and absent or solitary in CFH) and array-based comparative genomic hybridization profiles (frequent gains of 7 and 8q and losses of Xq in MetFH; recurrent losses of chromosomes 9 and 22 in AFH; isolated loss of 5q and gain in chromosome 20 in 2 CFH). Fatal MetFH cases (2 of 5 cases) exhibited the highest rate of chromosomal aberrations.
Limitations |
This study included a small sample size with a short-term follow-up.
Conclusions |
Benign CFH, indolent AFH, and MetFH represent distinct biological entities within the spectrum of FH; array-based comparative genomic hybridization may be a tool in recognizing FH cases with metastatic potential and increasingly aggressive behavior.
Le texte complet de cet article est disponible en PDF.Key words : array-based comparative genomic hybridization, atypical fibrous histiocytoma, cellular fibrous histiocytoma, fibrous histiocytoma, genomic instability, metastasizing fibrous histiocytoma
Abbreviations used : aCGH, AFH, CFH, FFPE, FH, MetFH
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 71 - N° 2
P. 256-263 - août 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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