Physical Activity Modifies the Associations between Genetic Variants and Blood Pressure in European Adolescents - 22/10/14
Doi : 10.1016/j.jpeds.2014.07.007
Augusto César Ferreira de Moraes, PhD 1, 2, 3, ⁎ 
, Juan Miguel Fernández-Alvira, PhD 2, 3, Heráclito Barbosa Carvalho, PhD 1, Aline Meirhaeghe, PhD 4, Jean Dallongeville, PhD 4, Anthony Kafatos, PhD 5, Ascensión Marcos, PhD 6, Dénes Molnar, PhD 7, Yannis Manios, PhD 8, Jonatan R. Ruiz, PhD 9, Idoia Labayen, PhD 10, Kurt Widhalm, PhD 11, Christina Breidenassel, PhD 12, Marcela Gonzalez-Gróss, PhD 12, 13, Luis A. Moreno, PhD 2, 3, ∗
, Juan Miguel Fernández-Alvira, PhD 2, 3, Heráclito Barbosa Carvalho, PhD 1, Aline Meirhaeghe, PhD 4, Jean Dallongeville, PhD 4, Anthony Kafatos, PhD 5, Ascensión Marcos, PhD 6, Dénes Molnar, PhD 7, Yannis Manios, PhD 8, Jonatan R. Ruiz, PhD 9, Idoia Labayen, PhD 10, Kurt Widhalm, PhD 11, Christina Breidenassel, PhD 12, Marcela Gonzalez-Gróss, PhD 12, 13, Luis A. Moreno, PhD 2, 3, ∗ 1 Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil
2 GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain
3 Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain
4 INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France
5 Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece
6 Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain
7 Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary
8 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
9 Promoting Fitness and Health through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain
10 Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain
11 Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria
12 Institut für Ernährungs-und Lebensmittelwissenschaften–Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
13 Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain
∗Reprint requests: Augusto César Ferreira de Moraes, PhD, Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil.
Abstract |
We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.
Le texte complet de cet article est disponible en PDF.Keyword : BP, DBP, HELENA, SBP
Plan
| The HELENA Study was supported by the European Community Sixth Research, Technological Development and Demonstration Framework Programme (FOOD-CT-2005-007034), the Spanish Ministry of Health: Maternal, Child Health, and Development Network (number RD08/0072), the Spanish Ministry of Education (EX-2008-0641 and RYC-2010-05957), and the Hjärt-Lungfonden (20090635). The GENUD Research Group was funded in part by the European Regional Development Fund (MICINN-FEDER). A.dM. received a scholarship from São Paulo Research Foundation (2011/11137-1 and 2011/20662-2). L.M. received a scholarship of visiting professor from Brazilian government by Science without Borders Program by National Counsel of Technological and Scientific Development and Coordination of Improvement of Higher Education Personnel (007/2012). The authors declare no conflicts of interest. |
© 2014
Elsevier Inc. Tous droits réservés.
Vol 165 - N° 5
P. 1046 - novembre 2014 Retour au numéro
Article précédent
- Pediatricians' Self-Reported Knowledge, Attitudes, and Practices about Child Passenger Safety
- Mark R. Zonfrillo, Erin K. Sauber-Schatz, Benjamin D. Hoffman, Dennis R. Durbin
- Compound Heterozygous Mutations in the SCN5A-Encoded Nav1.5 Cardiac Sodium Channel Resulting in Atrial Standstill and His-Purkinje System Disease
- Shankar Baskar, Michael J. Ackerman, Diane Clements, Kenneth A. Mayuga, Peter F. Aziz
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?