White Matter Microstructure and Cognition in Adolescents with Congenital Heart Disease - 22/10/14
Abstract |
Objective |
To describe the relationship between altered white matter microstructure and neurodevelopment in children with dextro-transposition of the great arteries (d-TGA).
Study design |
We report correlations between regional white matter microstructure as measured by fractional anisotropy (FA) and cognitive outcome in a homogeneous group of adolescents with d-TGA. Subjects with d-TGA (n = 49) and controls (n = 29) underwent diffusion tensor imaging and neurocognitive testing. In the group with d-TGA, we correlated neurocognitive scores with FA in 14 composite regions of interest in which subjects with d-TGA had lower FA than controls.
Results |
Among the patients with d-TGA, mathematics achievement correlated with left parietal FA (r = 0.39; P = .006), inattention/hyperactivity symptoms correlated with right precentral FA (r = −0.39; P = .006) and left parietal FA (r = −0.30; P = .04), executive function correlated with right precentral FA (r = −0.30; P = .04), and visual-spatial skills correlated with right frontal FA (r = 0.30; P = .04). We also found an unanticipated correlation between memory and right posterior limb of the internal capsule FA (r = 0.29; P = .047).
Conclusion |
Within the group with d-TGA, regions of reduced white matter microstructure are associated with cognitive performance in a pattern similar to that seen in healthy adolescents and adults. Diminished white matter microstructure may contribute to cognitive compromise in adolescents who underwent open-heart surgery in infancy.
Le texte complet de cet article est disponible en PDF.Keyword : ACC, ACT, ADHD, CADS-P, CHD, d-TGA, DTI, FA, MRI, PLIC, ROI, TVPS, WIAT
Plan
Supported by the National Heart, Lung, and Blood Institute (R01 HL77681), The Children's Heart Foundation (Chicago), and the Farb Family Fund. The authors declare no conflicts of interest. |
Vol 165 - N° 5
P. 936 - novembre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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