Family History of Prostate Cancer in Men Being Followed by Active Surveillance Does Not Increase Risk of Being Diagnosed With High-grade Disease - 28/03/15
Abstract |
Objective |
To assess whether men with a family history of prostate cancer are more likely to fail active surveillance because of recategorization of their tumors on subsequent surveillance biopsies.
Methods |
Men enrolled in an institutional review board–approved active surveillance program were studied, and data on first- and/or second-degree family history of prostate cancer was collected. Analyses were performed to compare the frequency of family history with recategorization (higher grade or volume disease) on surveillance biopsies.
Results |
Men with and without family history were recategorized with higher grade disease at a similar frequency (30.9% vs 32.8%). There was no evidence that men with a family history with higher grade disease had more aggressive pathology at the time of radical prostatectomy than men without a family history. Although those with a family history tended to have a shorter time period to recategorization with more positive cores, the difference was not significant.
Conclusion |
Our results suggest that men with a family history of prostate cancer are not at an increased risk for recategorization on active surveillance. Men with a family history of prostate cancer should not be deterred from considering active surveillance as a treatment option.
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Financial Disclosure: The authors declare that they have no relevant financial interests. |
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Funding Support: This study was supported by the John and Carol Walter Center for Urological Health, NorthShore University HealthSystem. |
Vol 85 - N° 4
P. 742-747 - avril 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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