Frequency-risk and duration-risk relations between occupational livestock contact and methicillin-resistant Staphylococcus aureus carriage among workers in Guangdong, China - 30/06/15
, Sidong Chen, PhD ⁎ Abstract |
Background |
Increasing evidence indicates a strong association between occupational livestock contact and methicillin-resistant Staphylococcus aureus (MRSA) carriage. However, it remains unclear whether there are frequency-risk and duration-risk relations between occupational livestock contact and human MRSA carriage.
Methods |
A cross-sectional survey was conducted in Guangdong, China, using a multistage sampling method. Participants were interviewed and provided a nasal swab for S aureus analysis. All MRSA isolates were genotyped by multilocus sequence typing. The dose-response relation was examined using logistic regression models.
Results |
Among the 1,860 participants, 1.4% of controls tested positive for MRSA (characterized as sequence type [ST] 59 and ST7), and 7% of workers with livestock contact tested positive for MRSA (characterized as ST9, ST59, and ST7). There was a 5.31 times increased risk of MRSA carriage corresponding to occupational livestock contact (odds ratio = 6.31; 95% confidence interval, 3.44-11.57) using no contact as reference. We found frequency and short-term duration of occupational livestock contact were associated with increased risk of MRSA carriage in a dose-response manner. These significant trends were observed consistently among workers with occupational pig contact. However, no long-term duration-risk increasing trend was observed for occupational livestock or pig contact.
Conclusion |
Our findings suggest that there may be dose-response relations between occupational livestock contact and human MRSA carriage. Nasal MRSA clonal complex 9 is not found in controls, but it is found in workers with livestock contact.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This study builds on previous literature to examine the possible dose-response relation between occupational livestock contact and human methicillin-resistant Staphylococcus aureus carriage. |
• | This observational study found that frequency and short-term duration of occupational livestock contact were associated with increased risk of methicillin-resistant Staphylococcus aureus carriage in a dose-response manner. |
• | Nasal livestock-associated methicillin-resistant Staphylococcus aureus CC9 is not found in controls, but it is found in workers with occupational livestock contact. |
Key Words : Community-acquired, Methicillin-resistant Staphylococcus aureus, Human, Livestock
Plan
| Funding/Support: This work was supported by the Natural Science Foundation of Guangdong Province (no. S2011010002481), the Innovation Fund of the Department of Education of Guangdong Province (no. 2013KJCX0112), and the Joint Natural Sciences Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University (no. GYFYLH201331). |
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| Disclaimer: The funders had no role in study design, data collection and analysis, and interpretation of the data. |
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| Conflicts of interest: None to report. |
Vol 43 - N° 7
P. 676-681 - juillet 2015 Retour au numéro
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